More histone structures
More histone structures
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更多组蛋白结构
DOI：
10.1016/0014-5793(79)80337-3
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发表时间：
1979
期刊：
影响因子：
3.5
通讯作者：
M. Strickland
中科院分区：
文献类型：
--
作者：
C. von Holt;W. N. Strickland;W. Brandt;M. Strickland
自从阐明了原型组蛋白 H3、H4、H2A 和 H2B 的氨基酸序列以来，关于这些结构变体出现的大量信息已经可用。（组蛋白一级结构细节的参考书目参见图 1-3；综述参见[341。）看来组蛋白 H3 和 H4 在广泛的进化过程中仅略有不同，而 组蛋白 H2A 和 H2B 经历了更广泛的进化变化（图 1-3）。结构的变化可以分为两种类型。第一组包括一个或几个残基的简单点突变或缺失。第二种类型的结构变异包括通过重复、插入、缺失和点突变对分子主要区域进行广泛的修饰。在某些变体中，这种变化导致了结构中新域的建立。
Since the elucidation of the amino acid sequence of the prototype histones H3, H4, H2A and H2B, a considerable amount of information on the occurrence of variants of these structures has become available.(Bibliographic references to details of the histone primary structures are given in fig. l-3; for review see [341.)It appears that the histones H3 and H4, over a wide range of evolution, vary only slightly whereas the histones H2A and H2B undergo more extensive evolutionary changes (fig. 1-3). The variations of the structures can be classified into two types. The first group comprises simple point mutations or deletions of one or several residues. The second type of structural variations consists in extensive modifications of major areas of the molecules through reiteration, insertion, deletion and point mutations. Such changes have led, in some variants, to the establishment of new domains in the structure.