Role of Telomeres and Telomerase in Aging and Cancer.
Role of Telomeres and Telomerase in Aging and Cancer.
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DOI：
10.1158/2159-8290.cd-16-0062
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发表时间：
2016-06
期刊：
影响因子：
28.2
通讯作者：
Shay JW
中科院分区：
文献类型：
--
作者：
Shay JW
端粒在人的一生中逐渐缩短。晚期恶性肿瘤的标志是连续细胞分裂的能力，其几乎普遍地与通过端粒酶的再活化而稳定端粒长度相关。人类端粒酶和较短端粒的抑制可能部分地作为抗癌保护机制而进化。虽然我们对端粒酶的调节还有很多不了解，但它仍然是癌症治疗的一个非常有吸引力的新靶点。本文综述了端粒酶领域的进展现状，确定了突出的问题，并提出了需要改进的领域和方法。
Telomeres progressively shorten throughout life. A hallmark of advanced malignancies is the ability for continuous cell divisions that almost universally correlates with the stabilization of telomere length by the reactivation of telomerase. The repression of telomerase and shorter telomeres in humans may have evolved in part as an anti-cancer protection mechanism. While there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeutics. This review focuses on the current state of advances in the telomerase area, identifies outstanding questions, and addresses areas and methods that need refinement.