Temporal and spatial changes in bone accrual, density, and strain energy density in growing foals
Temporal and spatial changes in bone accrual, density, and strain energy density in growing foals
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生长中的小马驹骨生成、密度和应变能密度的时间和空间变化
DOI：
10.1016/j.jmbbm.2019.103568
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发表时间：
2020
影响因子：
3.9
通讯作者：
Kersh, Mariana E.
中科院分区：
文献类型：
--
作者：
Moshage, Sara G.;McCoy, Annette M.;Polk, John D.;Kersh, Mariana E.
骨骼适应部分是由机械负荷驱动的，青年时期的锻炼已被证明对骨骼健康有终身的益处。然而，早期运动为基础的干预措施，减少赛马骨折的发生率的发展是有限的，缺乏正常发育的特点，在生长骨。以前量化马骨发育的努力依赖于重复的X光片或外周定量计算机断层扫描，这在评估整个骨骼方面受到限制。在这项研究中，我们获得了计算机断层扫描的三个Standardbred小跑小马纵向2至12个月的年龄。建立左前肢近节指骨的有限元模型，用于评估安静站立时的应变能密度。评价了骨骺远端、骨干中段和骨骺近端的骨密度和骨面积分数的生长相关变化。骨密度和骨面积分数均匀增加骨干和应变能密度是恒定的，在生长过程中，表明适应安静的立场。骨密度和骨面积分数在近端骺内侧象限增加，但在骨倾向外侧象限没有增加。所提供的数据提供了一个正常生长轨迹的基准，可用于评估生长期间训练方案的效果。
Bone adaptation is in part driven by mechanical loading, and exercise during youth has been shown to have life-long benefits for bone health. However, the development of early exercise-based interventions that reduce the incidence of fractures in racing horses is limited by the lack of characterization of normal development in growing bone. Previous efforts to quantify bone development in the horse have relied on repeated radiographs or peripheral quantitative computed tomography scans, which are limited in their assessment of the entire bone. In this study, we acquired computed tomography scans of three Standardbred trotting colts longitudinally between 2 and 12 months of age. Finite-element models were constructed of the left forelimb proximal phalanx and used to assess strain energy density during quiet standing. Growth related changes in mineral density and bone area fraction in the distal epiphysis, mid-diaphysis, and proximal epiphysis were evaluated. Mineral density and bone area fraction uniformly increased in the diaphysis and strain energy density was constant during growth, indicating adaptation to quiet standing. Bone mineral density and bone area fraction increased in the medial quadrant of the proximal epiphysis but not in the fracture-prone lateral quadrant. The data presented provides a benchmark of normal growth trajectories that can be used to evaluate the effect of training regimens during growth.