Blood pressure estimation based on pulse rate variation in a certain period
Blood pressure estimation based on pulse rate variation in a certain period
复制标题
DOI：
10.1038/s41598-020-58367-y
复制
发表时间：
2020-01-29
影响因子：
4.6
通讯作者：
Hayase, Toshiyuki
中科院分区：
文献类型：
--
作者：
Hayase, Toshiyuki
每日连续血压（DCBP）的可用性对健康社会的实现具有重要影响。然而，利用与脉搏波形、脉搏传导时间或脉搏率的相关性或循环模型的计算来获得袖带型和无袖带型的血压的现有方法不适合于获得DCBP。在这里，我们实现了一个简单的循环系统模型的基础上使用脉搏率测量的方法，以克服局限性，并表明它提供了适当的估计DCBP。本模型由循环动力系统模型和循环控制系统的逆模型组成，输入脉率和代表标准脉率、体动脉弹性、外周血管阻力、阻力和每搏输出量控制特性的六个模型参数。通过四天一名受试者和一天四名受试者的初步实验，检验了DCBP估计方法的有效性。通过可穿戴设备的24小时脉率测量和血压计测量进行DCBP估计，以确定和验证参数。收缩压/舒张压的平均绝对误差为9.4/6.4mmHg（4天）和7.3/5.9mmHg（5人）。
Availability of daily continuous blood pressure (DCBP) has a strong impact to realization of healthy society. However, existing methods to obtain blood pressure of cuff type and cuff-less types utilizing correlation with pulse waveform, pulse transit time or pulse rate; or computation of circulation model are not suitable to obtain DCBP. Here we implemented a method based on a simple circulatory system model using pulse rate measurement to overcome the limitations, and showed that it provides appropriate estimation of DCBP. The present model consists of a circulatory dynamic system model and an inverse model of a circulatory control system with input of pulse rate and six model parameters representing standard pulse rate, elasticity of systemic arteries, peripheral vascular resistance, and characteristics of resistance and stroke volume control. Validity of the DCBP estimation method was examined by preliminary experiment for one subject in four days and that for four subjects in one day. DCBP estimation was performed with 24-hour pulse rate measurement by a wearable device and sphygmomanometer measurement for parameter determination and verification. Mean absolute errors in systolic/diastolic pressures were appropriate ones for preliminary experiments with 9.4/6.4mmHg in four days and 7.3/5.9mmHg in five subjects.