Cytotoxic Indole Alkaloids from Melodinus tenuicaudatus
Cytotoxic Indole Alkaloids from Melodinus tenuicaudatus
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DOI：
10.1021/np100086x
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发表时间：
2010-06-01
影响因子：
5.1
通讯作者：
Luo, Xiao-Dong
中科院分区：
文献类型：
--
作者：
Feng, Tao;Li, Yan;Luo, Xiao-Dong
从细尾野Melodinus tenuicaudatus中分离出4种新的双吲哚生物碱：Melodinines H-K（1-4）、一种新单体Melodinine L（5）和11种已知生物碱。化合物1-5的结构经波谱学方法鉴定，并与文献数据进行了比较。评价了所有化合物对5种人癌细胞系生物碱3和4的细胞毒性，已知化合物11-甲氧基他勃松宁（8）表现出抑制作用，IC 50值与顺铂和长春瑞滨相当。
Four new bisindole alkaloids, melodinines H-K (1-4), a new monomer, melodinine L (5), and 11 known alkaloids were isolated from Melodinus tenuicaudatus. The structures of 1-5 were elucidated by extensive spectroscopic methods, and the known compounds were identified by comparison with data in the literature. All of the compounds were evaluated for their cytotoxicity against five human cancer cell lines, Alkaloids 3, and 4 and the known compound 11-methoxytabersonine (8) exhibited inhibitory effects, with IC50 values comparable to those of cisplatin and vinorelbine.