Multicenter linkage study of schizophrenia loci on chromosome 22q
Multicenter linkage study of schizophrenia loci on chromosome 22q
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DOI：
10.1038/sj.mp.4001481
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发表时间：
2004-08-01
影响因子：
11
通讯作者：
Levinson, DF
中科院分区：
文献类型：
--
作者：
Mowry, BJ;Holmans, PA;Levinson, DF
22q 染色体上存在一个或多个精神分裂症易感位点的假设得到了遗传连锁和关联报告、连锁荟萃分析以及对 22q11 微缺失引起的腭心面综合征患者精神病风险升高的观察的支持。我们通过评估 779 个家系的多中心样本中跨越 22q 的 10 个微卫星标记来检验这一假设。我们还将发病年龄和性别作为协变量纳入分析中。没有观察到与精神分裂症相关或与较早发病年龄、性别或不同地点异质性相关的显着证据。我们将这些发现解释为，假定的 22q 精神分裂症易感位点对人群的影响太弱，即使在大样本中也无法通过连锁分析检测到。
The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkage analysis even in large samples.