Serum thyroid-stimulating hormone receptor antibody levels and thyroid dysfunction after hysterosalpingography: a case-control study
Serum thyroid-stimulating hormone receptor antibody levels and thyroid dysfunction after hysterosalpingography: a case-control study
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子宫输卵管造影后血清促甲状腺激素受体抗体水平和甲状腺功能障碍：病例对照研究
DOI：
10.1080/09513590.2021.1963430
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发表时间：
2021
影响因子：
2
通讯作者：
Tawara Fumiko
中科院分区：
文献类型：
--
作者：
So Shuhei;Hashimoto Koshi;Mori Masatomo;Endo Shigeki;Yamaguchi Wakasa;Miyano Naomi;Murabayashi Nao;Tawara Fumiko
使用碘造影剂进行子宫输卵管造影（HSG）可导致甲状腺功能障碍，包括甲状腺毒症和甲状腺功能减退症。我们调查了血清促甲状腺激素受体抗体（TRAb）水平（Graves病的指标）与HSG后甲状腺功能异常之间的关系。方法对2018年4月至9月期间首次访问田原IVF诊所的362名患者进行TRAb筛查。结果在362例患者中，2例（0.55%）TRAb水平较高（> 2.0IU/L），18例（5.0%）TRAb水平中等（0.3 ~ 1.9IU/L）。在98名女性中，其中TRAb水平0.3-1.9 IU/L的18例中有7例，TRAb水平<0.3 IU/L的342例中有91例，HSG后有2例发生明显的甲状腺毒症，（p= 0.0044）在TRAb中等水平组中（2/7）高于低TRAb组（28.6%，2/7）（<0.3IU/L; 0.0%，0/91）.结论HSG后血清TRAb水平升高与甲状腺毒症的发生密切相关。
ObjectiveHysterosalpingography (HSG) performed with an iodine contrast media can cause thyroid dysfunction, including thyrotoxicosis and hypothyroidism. We investigated the association between the serum levels of thyroid-stimulating hormone receptor antibody (TRAb), an indicator of Graves’ disease, and abnormal thyroid function after performing HSG.MethodsThe screening of TRAb was conducted in 362 patients who first visited the Tawara IVF Clinic between April and September 2018. The association between TRAb levels and the effects of HSG examinations on thyroid function were evaluated.ResultsOf the 362 patients, 2 (0.55%) had high levels (>2.0 IU/L) of TRAb, whereas 18 (5.0%) had intermediate TRAb levels, ranging from 0.3 to 1.9 IU/L. Of the 98 women (including 7 of the 18 women with TRAb level 0.3–1.9 IU/L, and 91 of the 342 women with TRAb level <0.3 IU/L) who had undergone HSG, two women developed overt thyrotoxicosis after HSG, and the frequency was significantly higher (p= .0044) in the group with intermediate levels of TRAb (28.6%, 2 of 7) than that in the group with low TRAb levels (<0.3 IU/L; 0.0%, 0 of 91).ConclusionsThese findings indicate that increased serum levels of TRAb are significantly associated with the development of thyrotoxicosis after HSG.