Epstein-Barr Virus (EBV)-induced B-cell Lymphoproliferative Disorder Mimicking the Recurrence of EBV-associated Hemophagocytic Lymphohistiocytosis
Epstein-Barr Virus (EBV)-induced B-cell Lymphoproliferative Disorder Mimicking the Recurrence of EBV-associated Hemophagocytic Lymphohistiocytosis
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EB 病毒 (EBV) 诱导的 B 细胞淋巴细胞增殖性疾病，模仿 EBV 相关噬血细胞性淋巴组织细胞增多症的复发
DOI：
10.1097/mph.0000000000001075
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Kawano Yoshifumi
中科院分区：
文献类型：
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作者：
Yatsushiro Yuki;Nishikawa Takuro;Saito Aki;Nakazawa Yozo;Imadome Ken-Ichi;Nakagawa Shunsuke;Kodama Yuichi;Okamoto Yasuhiro;Kanegane Hirokazu;Kawano Yoshifumi
我们描述的情况下，23个月大的男婴与EB病毒（EBV）相关的淋巴组织增生性疾病，模仿复发的EBV相关的噬血细胞性淋巴组织细胞增生症。地塞米松、足叶乙甙和环孢霉素的化疗解决了发热、肝脾肿大和全血细胞减少。然而，在发病的第81天，患者出现了类似的症状。血浆EBV-DNA水平再次显著升高，但未观察到T细胞克隆性。B细胞被鉴定为被EBV感染。他成功地治疗利妥昔单抗，地塞米松和依托泊苷。当怀疑EBV相关的噬血细胞性淋巴组织细胞增多症复发时，进行检测以识别感染的细胞将能够准确了解临床状况，从而进行适当的治疗。
We describe the case of a 23-month-old male infant with Epstein-Barr virus (EBV)-associated lymphoproliferative disorder, which mimicked the recurrence of EBV-associated hemophagocytic lymphohistiocytosis. Chemotherapy with dexamethasone, etoposide, and cyclosporine resolved fever, hepatosplenomegaly, and pancytopenia. However, on day 81 of illness, the patient developed similar symptoms. Plasma EBV-DNA levels markedly increased again, but no T-cell clonality was observed. B cells were identified to be infected with EBV. He was successfully treated with rituximab, dexamethasone and etoposide. When recurrence of EBV-associated hemophagocytic lymphohistiocytosis is suspected, performing tests to identify the infected cells will enable accurate understanding of the clinical condition, resulting in proper treatments.