Complete Genome Sequence of Le Blanc Virus, a Third Caenorhabditis Nematode-Infecting Virus
Complete Genome Sequence of Le Blanc Virus, a Third Caenorhabditis Nematode-Infecting Virus
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DOI：
10.1128/jvi.02025-12
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发表时间：
2012-11-01
影响因子：
5.4
通讯作者：
Wang, David
中科院分区：
文献类型：
--
作者：
Franz, Carl J.;Zhao, Guoyan;Wang, David
奥赛病毒和Santeuil病毒是第一个已知的能够分别自然感染线虫秀丽隐杆线虫和布里格隐杆线虫的病毒，最近通过野生隐杆线虫株的高通量测序鉴定。通过对另一种野生C.在Briggsae分离株中，我们发现了第三种新病毒--勒布朗病毒，并对其全基因组进行了测序，该病毒与奥赛病毒和桑特伊病毒有较远的亲缘关系。所有三种病毒都是正义RNA病毒，具有与野田病毒最密切相关的二分基因组。鉴定能够感染小杆线虫的第三种病毒能够对该病毒分支进行比较分析，并加强了该模型用于调查病毒-宿主相互作用。
Orsay virus and Santeuil virus, the first known viruses capable of naturally infecting the nematodes Caenorhabditis elegans and Caenorhabditis briggsae, respectively, were recently identified by high-throughput sequencing of wild Caenorhabditis strains. By similar analysis of another wild C. briggsae isolate, we have now discovered and sequenced the complete genome of a third novel virus, Le Blanc virus, that is distantly related to Orsay and Santeuil viruses. All three viruses are positive-sense RNA viruses with bipartite genomes that are most closely related to nodaviruses. Identification of a third virus capable of infecting Caenorhabditis nematodes enables comparative analysis of this clade of viruses and strengthens this model for investigating virus-host interactions.