Different thresholds of Wnt-Frizzled 7 signaling coordinate proliferation, morphogenesis and fate of endoderm progenitor cells.
Different thresholds of Wnt-Frizzled 7 signaling coordinate proliferation, morphogenesis and fate of endoderm progenitor cells.
复制标题
Wnt-Frizz的不同阈值7信号传导坐标坐标增殖，形态发生和内胚层祖细胞的命运。
DOI：
10.1016/j.ydbio.2013.02.024
复制
发表时间：
2013-06-01
影响因子：
2.7
通讯作者：
Zorn, Aaron M.
中科院分区：
文献类型：
--
作者：
Zhang, Zheng;Rankin, Scott A.;Zorn, Aaron M.
Wnt信号在胃肠道和呼吸系统的发育过程中具有多种动态作用。差异Wnt信号传导被认为是非洲爪蟾内胚层模式化的关键步骤，使得在胚胎发生的原肠胚晚期和体节早期阶段，Wnt活性必须在前部被抑制以允许前肠祖细胞的特化。然而，前肠内胚层还表达Wnt受体Frizzled 7（Fzd 7）以及几种Wnt配体，这表明当前模型可能过于简单。在这项研究中，我们发现Fzd 7是维持低水平Wnt信号传导所必需的，这对维持前肠祖细胞至关重要。爪蟾前肠特异性Fzd 7缺失导致肝脏和胰腺发育不全。Fzd 7缺失的胚胎未能维持前肠祖细胞标记hhex，并表现出增殖减少;此外，前肠细胞以随机方向扩大。我们表明，在前肠中，Fzd 7信号通过Wnt/β-catenin和Wnt/JNK途径，并且Wnt-Fzd 7活性的不同阈值协调祖细胞命运、增殖和形态发生。
Wnt signaling has multiple dynamic roles during development of the gastrointestinal and respiratory systems. Differential Wnt signaling is thought to be a critical step in Xenopus endoderm patterning such that during late gastrula and early somite stages of embryogenesis, Wnt activity must be suppressed in the anterior to allow the specification of foregut progenitors. However, the foregut endoderm also expresses the Wnt-receptor Frizzled 7 (Fzd7) as well as several Wnt ligands suggesting that the current model may be too simple. In this study, we show that Fzd7 is required to transduce a low level of Wnt signaling that is essential to maintain foregut progenitors. Foregut-specific Fzd7-depletion from the Xenopus foregut resulted in liver and pancreas agenesis. Fzd7-depleted embryos failed to maintain the foregut progenitor marker hhex and exhibited decreased proliferation; in addition the foregut cells were enlarged with a randomized orientation. We show that in the foregut Fzd7 signals via both the Wnt/β-catenin and Wnt/JNK pathways and that different thresholds of Wnt-Fzd7 activity coordinate progenitor cell fate, proliferation and morphogenesis.
登录
查看更多内容
DOI：
10.1073/pnas.0602557103
发表时间：
2006-10-31
影响因子：
11.1
作者：
Liao, Guanghong;Tao, Qinghua;Kuan, Chia-Yi
通讯作者：
Kuan, Chia-Yi
影响因子：
11.8
作者：
Cheyette, BNR;Waxman, JS;Moon, RT
通讯作者：
Moon, RT
DOI：
10.1083/jcb.200403043
发表时间：
2004-12-20
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chu YS;Thomas WA;Eder O;Pincet F;Perez E;Thiery JP;Dufour S
通讯作者：
Dufour S
影响因子：
46.9
作者：
Kroon, Evert;Martinson, Laura A.;Baetge, Emmanuel E.
通讯作者：
Baetge, Emmanuel E.
DOI：
10.1083/jcb.200710188
发表时间：
2008-09-22
期刊：
The Journal of cell biology
影响因子：
--
作者：
Kim GH;Her JH;Han JK
通讯作者：
Han JK