Smartphone-based battery-free and flexible electrochemical patch for calcium and chloride ions detections in biofluids
Smartphone-based battery-free and flexible electrochemical patch for calcium and chloride ions detections in biofluids
复制标题
基于智能手机的无电池灵活电化学贴片，用于生物液中的钙离子和氯离子检测
DOI：
10.1016/j.snb.2019.126743
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发表时间：
2019-10-15
影响因子：
8.4
通讯作者：
Liu, Qingjun
中科院分区：
文献类型：
--
作者：
Xu, Gang;Cheng, Chen;Liu, Qingjun
过去十年，基于智能手机的生化传感系统的趋势不断增长。与此同时，腕带、贴片和纹身等柔性电化学传感设备已被广泛开发，用于对可访问的生物流体进行原位检测分析。对于这些设备来说，由于需要刚性电池或有线连接，因此很难同时实现与智能手机的连接和整个设备的灵活性。这里，开发了一种基于智能手机的无电池灵活电化学贴片，用于实时检测各种生物液中的钙离子和氯离子。该贴片集成了近场通信（NFC）模块、现场信号处理电路和全印刷可拉伸电极阵列，可以在拉伸过程中保持稳定的导电性，无需蛇形设计。该器件具有无线能量采集、现场信号处理和无线数据传输功能。支持 NFC 的智能手机可以为贴片无线供电，并通过天线之间的电感耦合获得检测结果。钙和氯传感器在目标离子的定量检测中表现出良好的灵敏度、重复性、选择性和稳定性。血清、尿液、泪液和汗液的异位测量表明与专用仪器具有良好的一致性。还使用贴片进行了实时体汗分析，进一步表明了该设备在可穿戴应用中的可用性和稳定性。该平台为基于智能手机的电化学传感系统提供了无电池、无线且灵活的解决方案，可应用于各种生物流体的快速分析。
Last decade has seen a growing trend toward smartphone-based biochemical sensing systems. Meanwhile, flexible electrochemical sensing devices like wristbands, patches, and tattoos have been widely developed for in situ detections of analyzes in accessible biofluids. For these devices, the connectivity with smartphone and the flexibility of the whole device are hard to achieve at the same time, due to the need for rigid batteries or wired connections. Here, a smartphone-based battery-free and flexible electrochemical patch is developed for real-time calcium and chloride ions detections in various biofluids. The patch is integrated with near field communication (NFC) module, on-site signal processing circuitry, and an all-printed stretchable electrode array which can maintain stable conductivity during stretching, without the need for serpentine designs. The device enables wireless power harvesting, on-site signal processing, and wireless data transmission capabilities. NFC-enabled smartphones can wirelessly power the patch and get the detection results through inductive coupling between antennas. The calcium and chloride sensors showed good sensitivity, repeatability, selectivity, and stability in quantitative detections of target ions. Ex situ measurements in serum, urine, tear, and sweat demonstrated good consistency with specialized instrument. Real-time on-body sweat analysis with the patch was also performed, which further indicated the usability and stability of the device in wearable applications. This platform provides a battery-free, wireless, and flexible solution for smartphone-based electrochemical sensing systems, which can be applied to rapid analysis of various biofluids.