Real-time monitoring and regulating auditory cortex alpha activity in patients with chronic tinnitus
Real-time monitoring and regulating auditory cortex alpha activity in patients with chronic tinnitus
复制标题
实时监测和调节慢性耳鸣患者听觉皮层α活性
DOI：
10.1088/1741-2552/ab57d5
复制
发表时间：
2020
影响因子：
4
通讯作者：
Birbaumer
中科院分区：
文献类型：
--
作者：
Malekshahi;Malekshahi;Czornik;Wolpert;Birbaumer
低水平的α活动（8- 13 Hz）反映了反应增强的状态，而高水平的α则反映了反应降低的状态。与正常听力对照组相比，耳鸣伴随着侧裂周区域的α活动减少。这种减少可能是导致耳鸣的反应链中的一个关键机制。我们设计了一种新的空间滤波器作为在线源监测方法，它可以用来控制初级听觉皮层的α活动。此外，我们设计了一个创新的实验程序，使抑制视觉和体感阿尔法，促进听觉阿尔法控制在阿尔法neurofeedback.ApproachAn调幅听觉刺激与40赫兹调制频率和1000赫兹载波频率专门激活初级听觉皮层。40 Hz振荡的地形图描绘了听觉皮层的活动。我们将这张地图用作空间过滤器，它传递来自听觉皮层的活动。为了抑制躯体感觉和视觉α对听觉α的叠加，我们使用了一个连续的触觉下颌刺激和视觉刺激协议，以抑制邻近听觉皮层和视觉α的区域的体感α，仅用于听觉α活动的局部调节。感觉刺激促进听觉皮层在传感器水平的α活动的出现。SignificanceThe建议的程序可以用于EEG神经反馈治疗方法，允许慢性耳鸣患者的在线听觉α自我调节训练。
ObjectiveLow levels of alpha activity (8–13Hz) mirror a state of enhanced responsiveness, whereas high levels of alpha are a state of reduced responsiveness. Tinnitus is accompanied by reduction of alpha activity in the perisylvian regions compared to normal hearing controls. This reduction might be a key mechanism in the chain of reactions leading to tinnitus. We devised a novel spatial filter as an on-line source monitoring method, which can be used to control alpha activity in the primary auditory cortex. In addition, we designed an innovative experimental procedure to enable suppression of visual and somatosensory alpha, facilitating auditory alpha control during alpha neurofeedback.ApproachAn amplitude-modulated auditory stimulation with 40 Hz modulation frequency and 1000 Hz carrier frequency specifically activates the primary auditory cortex. The topography of 40 Hz oscillation depicts the activity of the auditory cortices. We used this map as a spatial filter, which passes the activity originating from the auditory cortex. To suppress superposition of auditory alpha by somatosensory and visual alpha, we used a continuous tactile jaw-stimulation and visual stimulation protocol to suppress somatosensory alpha of regions adjacent to the auditory cortex and visual alpha for local regulation of auditory alpha activity only.Main resultsThis novel spatial filter for online detection of auditory alpha activity and the usage of multi-sensory stimulation facilitate the appearance of alpha activity from the auditory cortex at the sensor level.SignificanceThe proposed procedure can be used in an EEG-neurofeedback-treatment approach allowing online auditory alpha self-regulation training in patients with chronic tinnitus.
登录
查看更多内容
影响因子：
14.5
作者：
De Massari, Daniele;Ruf, Carolin A.;Birbaumer, Niels
通讯作者：
Birbaumer, Niels
影响因子：
5.1
作者：
Jatoi, Munsif Ali;Kamel, Nidal;Begum, Tahamina
通讯作者：
Begum, Tahamina
影响因子：
2.5
作者：
Lehtela, L;Salmelin, R;Hari, R
通讯作者：
Hari, R
影响因子：
1.2
作者：
Korczak, Peggy;Smart, Jennifer;Bradford, Christina
通讯作者：
Bradford, Christina
影响因子：
--
作者：
Vatta F;Meneghini F;Esposito F;Mininel S;Di Salle F
通讯作者：
Di Salle F