EXPRESSION OF 2 MYOGENIC REGULATORY FACTORS MYOGENIN AND MYOD1 DURING MOUSE EMBRYOGENESIS
EXPRESSION OF 2 MYOGENIC REGULATORY FACTORS MYOGENIN AND MYOD1 DURING MOUSE EMBRYOGENESIS
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DOI：
10.1038/341303a0
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发表时间：
1989-09-28
期刊：
影响因子：
64.8
通讯作者：
BUCKINGHAM, M
中科院分区：
文献类型：
--
作者：
SASSOON, D;LYONS, G;BUCKINGHAM, M
MyoDl和肌细胞生成素是肌肉特异性蛋白质，其可以将培养物中的非肌细胞转化为分化的肌纤维，使它们参与肌细胞生成决定。MyoD1和myogenin在小鼠体内胚胎和体外培养的肢芽外植体中肌肉形成早期的表达模式表明，它们可能在发育过程中的不同类型的肌肉中具有不同的功能。
MyoDl and myogenin are muscle-specific proteins which can convert non-myogenic cells in culture to differentiated muscle fibres, implicating them in myogenic determination. The pattern of expression of MyoDl and myogenin during the early stages of muscle formation in the mouse embryoin vivoand in limb-bud explants culturedin vitro, indicates that they may have different functions in different types of muscle during development.