PHOSPHORYLATION OF LARGE TUMOR-ANTIGEN BY CDC2 STIMULATES SV40 DNA-REPLICATION
PHOSPHORYLATION OF LARGE TUMOR-ANTIGEN BY CDC2 STIMULATES SV40 DNA-REPLICATION
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DOI：
10.1038/341503a0
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发表时间：
1989-10-12
期刊：
影响因子：
64.8
通讯作者：
BEACH, D
中科院分区：
文献类型：
--
作者：
MCVEY, D;BRIZUELA, L;BEACH, D
猿猴病毒40大肿瘤抗原(T)是病毒DNA合成所需的复制起始结合蛋白。未磷酸化的T抗原在体外缺乏促进DNA复制的功能，但可以通过cdc2蛋白激酶磷酸化苏氨酸124位点来激活。这一观察结果表明T受磷酸化调控，并为cdc2在控制DNA复制中的功能提供了一个模型。
Simian virus 40 large tumour antigen (T) is a replication origin binding protein required for viral DNA synthesis. Unphosphorylated T antigen is deficient in promoting DNA replicationin vitrobut can be activated by phosphorylation at residue threonine 124 by the cdc2 protein kinase. This observation demonstrates that T is regulated by phosphorylation and provides a model for cdc2 function in the control of DNA replication.