Scaling of Movement Is Related to Pallidal γ Oscillations in Patients with Dystonia
Scaling of Movement Is Related to Pallidal γ Oscillations in Patients with Dystonia
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DOI：
10.1523/jneurosci.3860-11.2012
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发表时间：
2012-01-18
影响因子：
5.3
通讯作者：
Kuehn, Andrea A.
中科院分区：
文献类型：
--
作者：
Bruecke, Christof;Huebl, Julius;Kuehn, Andrea A.
伽马（gamma）波段的神经元同步被认为对于通过跨不同脑区的神经元组装的功能整合进行信息处理是重要的。运动相关的伽马同步发生在人类基底神经节中，在那里它以类似于70 Hz的频率为中心，并且在移动的手的对侧更明显。然而，其在运动性能中的功能意义尚未得到很好的理解。在这里，我们评估了是否事件相关的伽玛同步（ERS）记录从苍白球内的患者接受脑深部电刺激的医学难治性原发性局灶性和节段性肌张力障碍可能编码特定的运动参数。在22例患者的选择反应时任务的性能记录苍白球局部场电位。前臂旋前-旋后运动的运动幅度以30度、60度和90度的角度进行参数调制。仅对肢体未受肌张力障碍影响的患者进行测试。运动开始时出现对侧γ波（35-105 Hz）ERS，运动峰值速度时达最大值。苍白球振荡伽马活动与运动参数相关：运动越大越快，伽马带的同步性越强。相比之下，事件相关的β带活动的减少是相似的所有运动。伽马波段活动没有改变与运动方向，并没有发生在被动运动。随着运动的大小和速度的逐步增加的γ活动表明在基底神经节控制正在进行的运动的缩放在这个频率范围内的神经元同步的作用。
Neuronal synchronization in the gamma (gamma) band is considered important for information processing through functional integration of neuronal assemblies across different brain areas. Movement-related gamma synchronization occurs in the human basal ganglia where it is centered at similar to 70 Hz and more pronounced contralateral to the moved hand. However, its functional significance in motor performance is not yet well understood. Here, we assessed whether event-related gamma synchronization (ERS) recorded from the globus pallidus internus in patients undergoing deep brain stimulation for medically intractable primary focal and segmental dystonia might code specific motor parameters. Pallidal local field potentials were recorded in 22 patients during performance of a choice-reaction-time task. Movement amplitude of the forearm pronation-supination movements was parametrically modulated with an angular degree of 30 degrees, 60 degrees, and 90 degrees. Only patients with limbs not affected by dystonia were tested. Abroad contralateral gamma band (35-105 Hz) ERS occurred at movement onset with a maximum reached at peak velocity of the movement. The pallidal oscillatory gamma activity correlated with movement parameters: the larger and faster the movement, the stronger was the synchronization in the gamma band. In contrast, the event-related decrease in beta band activity was similar for all movements. Gamma band activity did not change with movement direction and did not occur during passive movements. The stepwise increase of gamma activity with movement size and velocity suggests a role of neuronal synchronization in this frequency range in basal ganglia control of the scaling of ongoing movements.