Endocrine gene neurotensin: Molecular mechanisms and a model of intestinal differentiation
Endocrine gene neurotensin: Molecular mechanisms and a model of intestinal differentiation
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DOI：
10.1007/s00268-002-4055-3
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发表时间：
2002-07-01
影响因子：
2.6
通讯作者：
Evers, BM
中科院分区：
文献类型：
--
作者：
Evers, BM
神经降压肽（NT）是一种重要的肠道激素，影响胃肠（GI）分泌、运动和生长。本文综述了NT在胃肠道中的作用以及编码NT的基因的分布和定位（即，NT/N）。此外，还对NT/N基因表达的分子调控进行了讨论，重点介绍了NT/N基因表达调控的转录因子、信号转导途径以及基因甲基化的作用。我们的研究已经确定NT/N基因作为一个很好的分子模型，通过它来定义调节肠细胞分化的因素。对导致“模型”肠道基因（如NT/N）表达的细胞过程进行深入分析，可以更好地了解正常肠道发育和功能，并更清楚地定义导致肠道肿瘤形成的细胞事件。
The peptide neurotensin (NT) is an important intestinal hormone that affects gastrointestinal (GI) secretion, motility, and growth. This review describes the effects of NT in the G I tract and the distribution and localization of the gene encoding NT (i.e., NT/N). In addition, the molecular regulation of NT/N gene expression is discussed with special emphasis on the transcription factors, signal transduction pathways, and the role of gene methylation in modulating NT/N gene expression. Our studies have identified the NT/N gene as an excellent molecular model by which to define factors regulating intestinal cell differentiation. The in-depth analysis of the cellular processes leading to the expression of "model" intestinal genes, such as NT/N, can provide better understanding of normal gut development and function as well as defining more clearly the cellular events leading to gut neoplasia.