Neu differentiation factor (NDF), a dominant oncogene, causes apoptosis in vitro and in vivo.
Neu differentiation factor (NDF), a dominant oncogene, causes apoptosis in vitro and in vivo.
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DOI：
10.1084/jem.188.8.1535
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发表时间：
1998-10-19
期刊：
影响因子：
--
通讯作者：
Leder P
中科院分区：
文献类型：
--
作者：
Grimm S;Weinstein EJ;Krane IM;Leder P
Neu分化因子（NDF，也称为neuregulin）是一种有效的上皮细胞增殖诱导剂，并已显示在转基因小鼠中诱导乳腺癌。尽管有这种增殖作用，我们已经表明，一种新的亚型的NDF可以诱导细胞凋亡时，过表达。在这里，我们报告说，这种属性也延伸到其他NDF亚型和NDF的细胞质部分是主要负责的凋亡效应，而增殖活性很可能取决于NDF的分泌版本。根据这些相互矛盾的性质，我们发现NDF诱导的肿瘤在体内表现出广泛的凋亡。因此，NDF是一种癌基因，其失调可以诱导转化以及凋亡。
Neu differentiation factor (NDF, also called neuregulin) is a potent inducer of epithelial cell proliferation and has been shown to induce mammary carcinomas in transgenic mice. Notwithstanding this proliferative effect, we have shown that a novel isoform of NDF can induce apoptosis when overexpressed. Here we report that this property also extends to other NDF isoforms and that the cytoplasmic portion of NDF is largely responsible for the apoptotic effect, whereas the proliferative activity is likely to depend upon the secreted version of NDF. In accordance with these contradictory properties, we find that tumors induced by NDF display extensive apoptosis in vivo. NDF is therefore an oncogene whose deregulation can induce transformation as well as apoptosis.