Neural correlates of the prolonged salience of painful stimulation
Neural correlates of the prolonged salience of painful stimulation
复制标题
DOI：
10.1016/s1053-8119(03)00407-5
复制
发表时间：
2003-11-01
期刊：
影响因子：
5.7
通讯作者：
Davis, KD
中科院分区：
文献类型：
--
作者：
Downar, J;Mikulis, DJ;Davis, KD
从突显性的角度来看，疼痛是一类独特的感觉体验。非痛苦的躯体感觉刺激通常需要行为相关性或自愿注意来保持显著性。相反，即使没有明确的行为相关性或自愿注意，疼痛刺激往往具有持续的显着性。我们以前已经确定了一个额叶-顶叶-扣带回网络的区域响应短暂的非痛苦的感觉事件。该网络对任务相关性和感觉事件的新奇性敏感，并且可能代表感觉环境中事件的显著性。由于疼痛可以在很长一段时间内保持突出，我们假设这个网络应该对非疼痛刺激的发生或抵消表现出短暂的反应，但在整个疼痛刺激的持续时间内持续反应。为了验证这一假设，我们使用功能性MRI来检查这些区域对持续（60秒）疼痛和无痛经皮电神经刺激的反应。正如预测的那样，颞顶、下额叶和前扣带回皮质对非疼痛刺激的开始或抵消仅表现出短暂的反应，但在整个疼痛刺激期间表现出持续的反应。因此，这些区域对具有紧张性显著性的刺激表现出紧张性反应，支持这些区域在代表刺激显著性方面的一般作用。丘脑和壳核在疼痛刺激时也有紧张性反应，但在非疼痛刺激时没有。以前的研究表明基底神经节支持自愿持续注意。我们的研究结果表明，基底神经节可能发挥更普遍的作用，支持持续的显着性，无论是通过自愿或非自愿的机制。(C)2003年爱思唯尔公司All rights reserved.
Pain is a unique class of sensory experience from the perspective of salience. Nonpainful somatosensory stimuli usually require behavioral relevance or voluntary attention to maintain salience. In contrast, painful stimuli tend to have sustained salience even without explicit behavioral relevance or voluntary attention. We have previously identified a frontal-parietal-cingulate network of regions responding transiently to nonpainful sensory events. This network is sensitive to the task relevance and novelty of sensory events and likely represents the salience of events in the sensory environment. Since pain can remain salient for a prolonged period, we hypothesized that this network should show transient responses to the onset or offset of a nonpainful stimulus, but sustained responses throughout the duration of a painful stimulus. To test this hypothesis, we used functional MRI to examine the response of these regions to sustained (60-s) periods of painful and nonpainful transcutaneous electrical nerve stimulation. As predicted, the temporoparietal, inferior frontal, and anterior cingulate cortex showed only transient responses to the onset or offset of nonpainful stimulation, but a sustained response throughout the duration of painful stimulation. These regions therefore show tonic responses to stimuli with tonic salience, supporting a general role for these areas in representing stimulus salience. The thalamus and putamen also responded tonically throughout painful but not nonpainful stimulation. Previous studies have implicated the basal ganglia in supporting voluntary sustained attention. Our findings suggest that the basal ganglia may play a more general role in supporting sustained salience, whether through voluntary or involuntary mechanisms. (C) 2003 Elsevier Inc. All rights reserved.