New glycosides of the fungus Acremonium striatisporum isolated from a sea cucumber
New glycosides of the fungus Acremonium striatisporum isolated from a sea cucumber
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DOI：
10.1021/np0305324
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发表时间：
2004-06-01
影响因子：
5.1
通讯作者：
Elyakov, GB
中科院分区：
文献类型：
--
作者：
Afiyatullov, SS;Kalinovsky, AI;Elyakov, GB
从海参条斑隐孢菌KMM4401菌株中分离得到4个新的二萜苷类化合物，分别为绿烯苷R(1)、S(2)、T(3)和U(4)。根据HRFABMS、一维和二维核磁共振(H-1、C-13、DEPT、COSY-45、COSY-RCT、HSQC、HMBC和NOESY谱)和酸水解结果确定它们的结构为19-O-{β-D-吡喃葡萄糖基(1-->；6)-beta-D-altropyranosyl}-isopimara-7，15-diene-2alpha，3beta-diol(1)、19-O-beta-D-altropyranosyl-3-oxo-isopimara-8(14)，15-diene-7alpha-ol(2)、19-O-beta-D-altropyranosyl-3，7-dioxo-isopimara-8，15-diene(3)和19-O-beta-D-altropyranosyl-3，7-dioxo-isopimara-8(14)，15-diene(4)。并对其细胞毒活性进行了检测。
Four new diterpene glycosides, virescenosides R (1), S (2), T (3), and U (4), have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures have been elucidated on the basis of HRFABMS, 1D and 2D NMR (H-1, C-13, DEPT, COSY-45, COSY-RCT, HSQC, HMBC, and NOESY spectra), and the results of acidic hydrolysis as 19-O-{beta-D-glucopyranosyl(1-->6)-beta-D-altropyranosyl}-isopimara-7,15-diene-2alpha,3beta-diol (1), 19-O-beta-D-altropyranosyl-3-oxo-isopimara-8(14),15-diene-7alpha-ol (2), 19-O-beta-D-altropyranosyl-3,7-dioxo-isopimara-8,15-diene (3), and 19-O-beta-D-altropyranosyl-3,7-dioxo-isopimara-8(14),15-diene (4). The cytotoxic activity of the virescenosides was examined.