The SRC family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo
The SRC family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo
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DOI：
10.1016/s1097-2765(00)80213-0
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发表时间：
1999-10-01
期刊：
影响因子：
16
通讯作者：
Mostov, KE
中科院分区：
文献类型：
--
作者：
Luton, F;Vergés, M;Mostov, KE
多聚免疫球蛋白A（pIgA）跨上皮细胞的转胞吞作用由多聚免疫球蛋白受体（pIgR）介导。pIgA与pIgR的结合通过依赖于SRC家族的蛋白酪氨酸激酶（PTK）的信号转导途径刺激pIgA-pIgR复合物的转胞吞作用。在这里，我们将PTK鉴定为p62（是）。我们证明了啮齿动物肝脏中pIgR与p62（是）的特定物理和功能关联。对p62（是）基因敲除小鼠的分析显示，酪氨酸激酶活性与pIgR和pIgA的转胞吞作用的相关性显著降低。我们得出结论，p62（是）控制pIgA转胞吞作用在体内。
Transcytosis of polymeric immunoglobulin A (pIgA) across epithelial cells is mediated by the polymeric immunoglobulin receptor (pIgR). Binding of pIgA to pIgR stimulates transcytosis of the pIgA-pIgR complex via a signal transduction pathway that is dependent on a protein tyrosine kinase (PTK) of the SRC family. Here we identify the PTK as p62(yes). We demonstrate the specific physical and functional association of the pIgR with p62(yes) in rodent liver. Analysis of p62(yes) knockout mice revealed a dramatic reduction in the association of tyrosine kinase activity with the pIgR and in transcytosis of pIgA. We conclude that p62(yes) controls pIgA transcytosis in vivo.