Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women's Health Study
Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women's Health Study
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DOI：
10.3945/ajcn.2008.27361
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发表时间：
2009-06-01
影响因子：
7.1
通讯作者：
Zheng, Wei
中科院分区：
文献类型：
--
作者：
Lee, Sang-Ah;Shu, Xiao-Ou;Zheng, Wei
背景：大豆食品是异黄酮的丰富来源，异黄酮是一类植物雌激素，具有抗雌激素和抗癌特性。目的：目的是在参加上海妇女健康研究的 73,223 名中国女性中，评估青少年和成人大豆食品摄入量与乳腺癌风险的关系。设计：使用经过验证的食物频率问卷来评估成年和青春期的日常饮食摄入量。经过平均 7.4 年的随访，使用 Cox 回归确定了 592 例乳腺癌病例，进行纵向分析。结果：通过大豆蛋白或异黄酮摄入量衡量的成人大豆食品消费量与绝经前乳腺癌风险呈负相关，且这种关联具有高度统计显着性（趋势 P < 0.001）。与最低五分位摄入量相比，大豆蛋白摄入量的多变量调整相对风险 (RR) 为 0.41 (95% CI: 0.25, 0.70)，异黄酮摄入量为 0.44 (95% CI: 0.26, 0.73)。青春期大量摄入大豆食品也与绝经前乳腺癌风险降低相关（RR：0.57；95% CI：0.34，0.97）。在青春期和成年期持续食用大量大豆食品的女性患乳腺癌的风险大大降低。未发现大豆食品摄入与绝经后乳腺癌存在显着关联。结论：这项大型、基于人群的前瞻性队列研究提供了强有力的证据，证明大豆食品摄入对绝经前乳腺癌具有保护作用。美国临床营养杂志 2009； 89：1920-6。
Background: Soy food is a rich source of isoflavones-a class of phytoestrogens that has both antiestrogenic and anticarcinogenic properties.Objective: The objective was to evaluate the association of adolescent and adult soy food intake with breast cancer risk in a cohort of 73,223 Chinese women who participated in the Shanghai Women's Health Study.Design: A validated food-frequency questionnaire was used to assess usual dietary intake during adulthood and adolescence. After a mean follow-up of 7.4 y, 592 incident cases of breast cancer were identified for longitudinal analyses by using Cox regressions.Results: Adult soy food consumption, measured either by soy protein or isoflavone intake, was inversely associated with the risk of premenopausal breast cancer, and the association was highly statistically significant (P for trend < 0.001). The multivariate-adjusted relative risks (RRs) for the upper intake quintile compared with the lowest quintile were 0.41 (95% CI: 0.25, 0.70) for soy protein intake and 0.44 (95% CI: 0.26, 0.73) for isoflavone intake. High intake of soy foods during adolescence was also associated with a reduced risk of premenopausal breast cancer (RR: 0.57; 95% CI: 0.34, 0.97). Women who consumed a high amount of soy foods consistently during adolescence and adulthood had a substantially reduced risk of breast cancer. No significant association with soy food consumption was found for postmenopausal breast cancer.Conclusion: This large, population-based, prospective cohort study provides strong evidence of a protective effect of soy food intake against premenopausal breast cancer. Am J Clin Nutr 2009; 89: 1920-6.