EFFECT OF MUTATIONS AFFECTING THE P6 GAG PROTEIN ON HUMAN-IMMUNODEFICIENCY-VIRUS PARTICLE RELEASE
EFFECT OF MUTATIONS AFFECTING THE P6 GAG PROTEIN ON HUMAN-IMMUNODEFICIENCY-VIRUS PARTICLE RELEASE
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DOI：
10.1073/pnas.88.8.3195
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发表时间：
1991-04-01
影响因子：
11.1
通讯作者：
HASELTINE, WA
中科院分区：
文献类型：
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作者：
GOTTLINGER, HG;DORFMAN, T;HASELTINE, WA
人类免疫缺陷病毒1型衣壳前体蛋白C端序列突变影响病毒p6蛋白，阻止出芽病毒颗粒从细胞表面释放。本文报道的实验确定了病毒生命周期中的一个重要步骤，即从将组装的颗粒绑定在细胞表面的系绳中释放出发芽颗粒。干扰素- α对病毒衣壳蛋白释放的抑制表明病毒成熟的这一步可能对抗病毒药物的抑制很敏感。
Mutations in sequences at the C terminus of the capsid precursor protein of human immunodeficiency virus type 1 that affect the viral p6 protein prevent release of budded virus particles from the cell surface. The experiments reported here define an important step in the life cycle of the virus, the release of the budded particle from a tether that binds the assembled particle to the cell surface. Inhibition of the release of the viral capsid proteins by interferon-alpha indicates that this step of virus maturation may be sensitive to inhibition by antiviral drugs.