A SELECTED ION MONITORING GC/MS ASSAY FOR 3,4,4'-TRICHLOROCARBANILIDE AND ITS METABOLITES IN BIOLOGICAL-FLUIDS
A SELECTED ION MONITORING GC/MS ASSAY FOR 3,4,4'-TRICHLOROCARBANILIDE AND ITS METABOLITES IN BIOLOGICAL-FLUIDS
复制标题
DOI：
10.1093/jat/11.2.75
复制
发表时间：
1987-03-01
影响因子：
2.5
通讯作者：
CORBIN, NC
中科院分区：
文献类型：
--
作者：
GRUENKE, LD;CRAIG, JC;CORBIN, NC
以氘标记化合物为内标物，建立了测定人血浆和尿液中3，4，4“-三氯苯胺脲（TCC）及其主要代谢产物（2”-羟基硫酸酯和N-和N“-葡萄糖醛酸苷）的选择离子监测气相色谱/质谱法。尿液中N-葡萄糖醛酸苷的检测限为3 ng/mL，血浆中2“-羟基硫酸盐的检测限为1.5 ng/mL。在使用含TCC的条皂的人类受试者的研究中说明了该方法的使用。
A selected ion monitoring gas chromatography/mass spectrometric method for the quantitative determination of 3,4,4''-trichlorocarbanilide (TCC) and its major metabolites (the 2''-hydroxy sulfate and the N- and N''-glucuronides) in human plasma and urine was developed using the deuterium-labelled compounds as internal standards. Limits of detection of 3 ng/mL in urine for the N-glucuronides and of 1.5 ng/mL in plasma for the 2''-hydroxy sulfate were attained. Use of the method was illustrated in a study in human subjects employing TCC-containing bar soaps.