AMP-activated protein kinase in the control of cardiac metabolism and remodeling.
AMP-activated protein kinase in the control of cardiac metabolism and remodeling.
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DOI：
10.1007/s11897-012-0102-z
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发表时间：
2012-09-01
影响因子：
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通讯作者：
Bertrand, Luc
中科院分区：
文献类型：
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作者：
Horman, Sandrine;Beauloye, Christophe;Bertrand, Luc
AMP活化蛋白激酶（AMPK）首先被认为是细胞燃料计。AMPK迅速感知能量剥夺并协调代谢反应，以维持细胞在这种不利条件下存活所需的可接受能量水平。其在心肌缺血期间的保护作用已被深入证实。最近，已经表明AMPK的作用扩展到与其他心脏病理相关的几种非代谢作用，包括糖尿病心肌病、心脏肥大和心力衰竭。本文就AMPK在正常和病理状态下心脏代谢和功能调控中的不同作用作一综述。AMPK的潜在心脏保护作用及其能量和非代谢作用在这些机制中的相对重要性进行了深入讨论。
The AMP-activated protein kinase (AMPK) can be firstly considered as a cellular fuel gauge. AMPK rapidly senses energy deprivation and orchestrates a metabolic response to maintain an acceptable energy level required for cell survival under such adverse condition. Its protective role during myocardial ischemia has been deeply documented. More recently, it has been shown that the role of AMPK extends to several nonmetabolic effects related to other cardiac pathologies comprising diabetic cardiomyopathy, cardiac hypertrophy, and heart failure. Here, we briefly review the different roles played by AMPK in the control of cardiac metabolism and function under normal and pathological conditions. The potential cardioprotective actions of AMPK and the relative importance of its energetic and nonmetabolic effects in these mechanisms are deeply discussed.