EFFECT OF ETHANOL ON THE SODIUM AND POTASSIUM CONDUCTANCES OF THE SQUID AXON MEMBRANE.
EFFECT OF ETHANOL ON THE SODIUM AND POTASSIUM CONDUCTANCES OF THE SQUID AXON MEMBRANE.
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DOI：
10.1085/jgp.48.2.279
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发表时间：
1964-11
期刊：
影响因子：
--
通讯作者：
TAKATA M
中科院分区：
文献类型：
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作者：
MOORE JW;ULBRICHT W;TAKATA M
采用蔗糖间隙技术研究了乙醇对鱿鱼巨轴突的影响。海水中的乙醇使膜动作电位高度适度降低，持续时间有时缩短。电压钳实验表明，海水中的乙醇降低了钠（g 'Na）和钾（g' K）的最大膜电导。在将乙醇多次施加到膜的同一点的实验中，3%的乙醇使海水中g 'Na和g' K分别减少到其值的82%和80 6%的乙醇使g 'Na下降到59%，g' K下降到69%。g Na的状态失活（作为调节膜电位的函数）或动力学参数如τh或开启g Na和g K的时间过程。得出的结论是，乙醇主要减少克钠和克钾在霍奇金-赫胥黎术语。
The effects of ethanol on squid giant axons were studied by means of the sucrose-gap technique. The membrane action potential height is moderately reduced and the duration sometimes shortened by ethanol in sea water. Voltage clamp experiments showed that ethanol in sea water reduced the maximum membrane conductances for sodium (g'Na) and potassium (g'K). In experiments with multiple application of ethyl alcohol to the same spot of membrane, a reduction of g'Na to 82 per cent and of g'K to 80 per cent of their value in sea water was brought about by 3 per cent ethanol (by volume) while 6 per cent caused a decrease of g'Na to 59 per cent and of g'K to 69 per cent. Ethanol has no significant effect on the steady-state inactivation of g Na (as a function of conditioning membrane potential) or on such kinetic parameters as τh or the time course of turning on gi g Na and g K. It is concluded that ethanol mainly reduces g Na and g K in the Hodgkin-Huxley terminology.