INTESTINAL FLORAS OF POPULATIONS THAT HAVE A HIGH-RISK OF COLON-CANCER
INTESTINAL FLORAS OF POPULATIONS THAT HAVE A HIGH-RISK OF COLON-CANCER
复制标题
DOI：
10.1128/aem.61.9.3202-3207.1995
复制
发表时间：
1995-09-01
影响因子：
4.4
通讯作者：
MOORE, LH
中科院分区：
文献类型：
--
作者：
MOORE, WEC;MOORE, LH
比较了息肉患者、日本夏威夷人、北美白种人、日本农村人和非洲农村人的粪便菌群。息肉患者和日本夏威夷人被认为是结肠癌高风险群体，日本农村人和非洲农村人被认为是低风险群体。北美白种人的菌群组成介于这两个群体之间。人类粪便菌群中的 15 种细菌类群与结肠癌高风险显着相关；其中五项与结肠癌的低风险显着相关。令人惊讶的是，拟杆菌属和双歧杆菌属的总浓度通常与结肠癌风险增加呈正相关。一些乳杆菌属和产气真杆菌也产生大量乳酸，它们与结肠癌的低风险密切相关。
The fecal floras of polyp patients, Japanese-Hawaiians, North American Caucasians, rural native Japanese, and rural native Africans were compared. The polyp patients and Japanese-Hawaiians were considered to be groups at high risk of colon cancer, and the rural native Japanese and rural native Africans were considered to be groups at low risk The North American Caucasians were found to have a flora composition intermediate between these two groups, Fifteen bacterial taxa from the human fecal flora were significantly associated with high risk of colon cancer; and five were significantly associated with low risk of colon cancer. Total concentrations of Bacteroides species and, surprisingly, Bifidobacterium species were generally positively associated with increased risk of colon cancer. Some Lactobacillus species and Eubacterium aerofaciens, which also produces major amounts of lactic acid, showed closest associations with low risk of colon cancer.