Endopeptidase-24.15 in rat hypothalamic/pituitary/gonadal axis.
Endopeptidase-24.15 in rat hypothalamic/pituitary/gonadal axis.
复制标题
大鼠下丘脑/垂体/性腺轴中的肽链内切酶-24.15。
DOI：
10.1016/0303-7207(91)90264-s
复制
发表时间：
1991
影响因子：
4.1
通讯作者：
Molineaux,CJ
中科院分区：
文献类型：
--
作者：
Pierotti,AR;Lasdun,A;Ayala,JM;Roberts,JL;Molineaux,CJ
Endopeptidase-24.15 (E.C. 3.4.24.15; EP-24.15) cleaves several substrates found in the hypothalamic/pituitary/gonadal axis, including gonadotropin-releasing hormone (GnRH) and the opioid peptides of the dynorphin family. We have examined the activity of EP-24.15 in these tissues as a function of maturation, of the estrous cycle, and in response to ovariectomy and estrogen replacement. A developmental regulation of EP-24.15-specific activity is apparent in anterior pituitary, in hypothalamus, and in the gonads. EP-24.15 is increased in the preoptic area and is decreased in the anterior pituitary in both male and female rats prior to puberty. The specific activity of EP-24.15 was increased following ovariectomy in the anterior pituitary and within medial and lateral preoptic nuclei. Testicular specific activity of EP-24.15 increased with age in a linear fashion, while ovarian EP-24.15 activity increased immediately prior to puberty, but returned to prepubertal levels by 65 days of age. The relevance of EP-24.15 to the metabolism of specific peptides is discussed.
