Enantioselective C-C bond cleavage creating chiral quaternary carbon centers
Enantioselective C-C bond cleavage creating chiral quaternary carbon centers
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DOI：
10.1021/ol061359g
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发表时间：
2006-07-20
期刊：
影响因子：
5.2
通讯作者：
Murakami, Masahiro
中科院分区：
文献类型：
--
作者：
Matsuda, Takanori;Shigeno, Masanori;Murakami, Masahiro
通过含硼取代的环丁酮的不对称分子内加成/开环反应生成了一个手性全碳的苄基季碳中心，该反应涉及对称的环丁酸铑的对映体选择性消除。该不对称反应成功地应用于倍半萜(-)-α-赫伯烯醇的合成。
A chiral all-carbon benzylic quaternary carbon center is created by the asymmetric intramolecular addition/ring-opening reaction of a borylsubstituted cyclobutanone, which involves enantioselective ss-carbon elimination from a symmetrical rhodium cyclobutanolate. The asymmetric reaction was successfully applied to a synthesis of sesquiterpene, (-)-alpha-herbertenol.