Placental transfer of C14-ethanol.
Placental transfer of C14-ethanol.
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C14-乙醇的胎盘移植。
DOI：
10.1016/0002-9378(71)90746-0
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发表时间：
1971
影响因子：
9.8
通讯作者：
W. McIsaac
中科院分区：
文献类型：
--
作者：
J. E. Idänpäan;G. E. Fritchie;B. Ho;W. McIsaac
在怀孕的最后30天内，通过静脉给6只猴子注射12%的乙醇-1-14C生理盐水溶液；在15分钟、90分钟或12小时处死它们，取出并冷冻胎儿和胎盘。对矢状切片进行放射自显影，并将未切片的组织匀浆并测定14 C。在妊娠第6天或第15天，对2组28只仓鼠进行腹膜内注射50％乙醇- 14 C盐水溶液，并将其处死并测定其组织中的 14 C。在注射后的前 30 分钟内，胎儿仓鼠的未变化乙醇含量高于母体大脑，并且妊娠晚期胎儿未变化乙醇浓度高于胎盘发育前。仓鼠和猴胎儿的乙醇代谢和排泄速度比母体慢，胎盘和羊水中的乙醇含量较高。胎儿体内较高浓度的乙醇-14C 及其代谢物存在于肝脏、胰腺、肾脏、肺、胸腺、心肌和肠壁，中枢神经系统的最大吸收是在小脑。 W.
A 12% solution of ethanol-1-14C in normal saline was given by vein to 6 monkeys during the last 30 days of pregnancy; they were killed at 15 min, 90 min or 12 h and foetuses and placentae were removed and frozen. Sagittal sections were autoradiographed and unsectioned tissues were homogenized and assayed for14C. On the 6th or 15th day of pregnancy 2 groups of 28 hamsters were given a 50% solution of ethanol-14C in saline intraperitoneally and were killed and their tissues were assayed for14C. The fetal hamster had more unchanged ethanol than the maternal brain during the first 30 min after injection and fetal concentration of unchanged ethanol was higher in late pregnancy than before the placenta developed. Ethanol metabolism and excretion were slower in hamster and monkey foetuses than in the mothers and placenta and amniotic fluid had high ethanol contents. Higher concentrations of ethanol-14C and metabolites in the fetus were found in liver, pancreas, kidney, lung, thymus, myocardium and intestinal wall and the greatest uptake in the central nervous system was in the cerebellum.-P. W.