Neuronal competition and selection during memory formation
Neuronal competition and selection during memory formation
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DOI：
10.1126/science.1139438
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发表时间：
2007-04-20
期刊：
影响因子：
56.9
通讯作者：
Josselyn, Sheena A.
中科院分区：
文献类型：
--
作者：
Han, Jin-Hee;Kushner, Steven A.;Josselyn, Sheena A.
神经元之间的竞争对于在发育过程中完善神经回路是必要的，并且对于选择参与成年大脑中编码记忆的神经元可能很重要。为了研究记忆形成过程中的神经元竞争，我们对小鼠进行了实验，在这些实验中，我们操纵了神经元亚群中CREB（腺苷3 '，5'-单磷酸反应元件结合蛋白）的功能。CREB功能的变化影响了个体杏仁核外侧核神经元被招募到恐惧记忆痕迹中的概率。我们的研究结果表明，一个竞争性模型的基础记忆的形成，其中合格的神经元被选择参与记忆痕迹作为其相对CREB活性的函数在学习的时候。
Competition between neurons is necessary for refining neural circuits during development and may be important for selecting the neurons that participate in encoding memories in the adult brain. To examine neuronal competition during memory formation, we conducted experiments with mice in which we manipulated the function of CREB ( adenosine 3',5'-monophosphate response element-binding protein) in subsets of neurons. Changes in CREB function influenced the probability that individual lateral amygdala neurons were recruited into a fear memory trace. Our results suggest a competitive model underlying memory formation, in which eligible neurons are selected to participate in a memory trace as a function of their relative CREB activity at the time of learning.