Outreach and support in South London (OASIS), 2001-2011: Ten years of early diagnosis and treatment for young individuals at high clinical risk for psychosis
Outreach and support in South London (OASIS), 2001-2011: Ten years of early diagnosis and treatment for young individuals at high clinical risk for psychosis
复制标题
DOI：
10.1016/j.eurpsy.2012.08.002
复制
发表时间：
2013-06-01
影响因子：
7.8
通讯作者：
McGuire, P. K.
中科院分区：
文献类型：
--
作者：
Fusar-Poli, P.;Byrne, M.;McGuire, P. K.
前言：精神病的预防已成为现代临床精神病学的主要目标。在欧洲和世界各地建立了越来越多的新服务。OASIS团队已成为精神病预防干预领域的临床实践和研究充分结合的既定模式。方法：综合分析2001-2011年绿洲团队实施的不同临床和服务措施。结果：在过去的十年中，OASIS团队共接收了1102例转诊，其中大多数是少数民族的年轻男性。经过评估，35%的人被诊断为有风险的精神状态（ARMS），而32%的人已经是精神病患者。在ARMS中，70%符合减轻精神病症状亚组的纳入标准，1%符合遗传恶化综合征的纳入标准，9%符合短暂和自限性间歇性精神病发作的纳入标准，其余符合多个亚组的纳入标准。他们中的大多数至少有一种共病诊断，主要与焦虑和抑郁领域有关。大多数OASIS患者单独接受认知行为治疗或与抗抑郁药/抗精神病药联合使用。在2年的随访时间里，44名受试者（15.2%）出现了坦率的精神病发作。结论：OASIS服务代表了世界上最大和最成熟的前驱服务之一。研究证据的负担和对临床实践产生的转化影响支持OASIS作为开发类似服务的典范。(C) 2012年由Elsevier Masson SAS出版。
Introduction: Prevention of psychosis has become a major objective of modern clinical psychiatry. An increasing number of new services have been established in Europe and in the world. The OASIS team has become an established model where clinical practice and research are fully integrated in the field of preventative interventions in psychosis.Method: Comprehensive analysis of different clinical and service measures describing the 2001-2011 implementation of the OASIS team.Results: Over the last decade, the OASIS team has received a total of 1102 referrals, mostly young males from ethnic minorities. After the assessment, 35% were diagnosed with an At Risk Mental State (ARMS) while 32% were already psychotic. Within the ARMS, 70% met the inclusion criteria for the attenuated psychotic symptoms subgroup, 1% met the inclusion criteria for the genetic deterioration syndrome, 9% met inclusion criteria for a brief and self-limited intermittent psychotic episode and the others met inclusion criteria for more than one subgroup. Most of them had at least one comorbid diagnosis, mainly relating to anxiety and depressive domains. The majority of the OASIS clients received cognitive behavioural therapy alone or in combination with antidepressants/antipsychotics. Over the 2-year follow-up time, 44 subjects (15.2%) developed a frank psychotic episode.Conclusions: The OASIS service represents one of the largest and most established prodromal services in the world. The burden of research evidence and the translational impact produced on the clinical practice support the OASIS as a model for the development of similar services. (C) 2012 Published by Elsevier Masson SAS.