HLA class II and TNF genes in African Americans from the Southeastern United States: Regional differences in allele frequencies
HLA class II and TNF genes in African Americans from the Southeastern United States: Regional differences in allele frequencies
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DOI：
10.1016/s0198-8859(03)00056-9
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发表时间：
2003-06-01
期刊：
影响因子：
2.7
通讯作者：
McNicholl, J
中科院分区：
文献类型：
--
作者：
Kuffner, T;Whitworth, W;McNicholl, J
群体主要组织相容性复合体基因频率的知识是重要的器官供体库的建设和疾病的关联研究。对来自美国东南部的112名健康、无关的非裔美国人（AA）进行人类白细胞抗原DRB 1（HLA-DRB 1）、HLA-DQB 1和TNF α-308（G-A）启动子基因分型。将等位基因频率与其他AA人群的已发表频率数据进行比较。我们的AA人群中HLA-DRB 1 *09的频率最高（6.7%），在任何AA人群中报告。TNF α-308A多态性的频率也很高（14.4%），与公布的频率在AA。HLA-DRB 1和HLA-DQB 1等位基因的分布在所有AA人群中观察到显着的地区差异。AA HLA-DRB 1和-DQB 1频率也不同于已发表的高加索人频率。这是第一份报告描述的分布TNF α启动子等位基因在美国东南部。我们人群的高DRB 1 *09和TNF α-308A等位基因频率与某些西非人群中这些等位基因的频率最相似。这些不同的主要组织相容性复合体基因频率可能反映了美国AA之间不同的区域人口结构，这可能是由于祖先起源，迁移和种族混合的差异。(C)美国组织相容性和免疫遗传学学会，2003年。爱思唯尔公司出版
Knowledge of population major histocompatibility complex gene frequencies is important for construction of organ donor pools and for studies of disease association. Human leukocyte antigen DRB1 (HLA-DRB1), HLA-DQB1, and TNFalpha-308 (G-A) promoter genetic typing was performed in 112 healthy, unrelated African Americans (AAs) from the southeastern United States. Allele frequencies were compared with published frequency data from other AA populations. Our AA population had the highest frequency of HLA-DRB1*09 (6.7%) reported in any AA population. The frequency of the TNFalpha -308A polymorphism was also high (1 4.4%), when compared with published frequencies in AAs. Significant regional differences in the distribution of most HLA-DRB1 and HLA-DQB1 alleles were observed in all AA populations examined. The AA HLA-DRB1 and -DQB1 frequencies also differed from published Caucasian frequencies. This is the first report describing the distribution of TNFalpha promoter alleles in the Southeastern United States. The high DRB1*09 and TNFalpha -308A allele frequencies of our population most resemble the frequencies of these alleles in certain West African populations. These varying major histocompatibility complex gene frequencies may reflect different regional population structures among AAs in the United States, which may be due to differences in ancestral origins, migration, and racial admixture. (C) American Society for Histocompatibility and Immunogenetics, 2003. Published by Elsevier Inc.