MAPKs in development: insights from Dictyostelium signaling pathways.
MAPKs in development: insights from Dictyostelium signaling pathways.
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DOI：
10.1515/bmc.2011.004
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发表时间：
2011-04-01
影响因子：
--
通讯作者：
Nguyen HN
中科院分区：
文献类型：
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作者：
Hadwiger JA;Nguyen HN
丝裂原活化蛋白激酶（Mitogen activated protein kinases，MAPKs）通过调节外界信号刺激下的信号转导通路，在真核生物的发育过程中发挥重要作用。MAPK信号通路与细胞生长、分化和趋化性的调节有关，表明MAPK参与多种发育过程。在大多数真核生物中，外部信号的多样性可能远远超过MAPK的多样性，这表明多种信号通路可能共享MAPK。不同的信号通路在MAPK功能之前会聚，还是MAPK可以通过与特定蛋白质的相互作用来保持信号特异性？在简单的真核生物，如网骨藻MAPK通路的遗传和生化分析提供了机会，调查G蛋白介导的信号转导通路中的MAPK的功能特异性。本文综述了丝裂原活化蛋白激酶在控制网骨藻生长和发育的途径中的调节作用和特异性。
Mitogen activated protein kinases (MAPKs) play important roles in the development of eukaryotic organisms through the regulation of signal transduction pathways stimulated by external signals. MAPK signaling pathways have been associated with the regulation of cell growth, differentiation, and chemotaxis, indicating MAPKs contribute to a diverse set of developmental processes. In most eukaryotes, the diversity of external signals is likely to far exceed the diversity of MAPKs, suggesting that multiple signaling pathways might share MAPKs. Do different signaling pathways converge before MAPK function or can MAPKs maintain signaling specificity through interactions with specific proteins? The genetic and biochemical analysis of MAPK pathways in simple eukaryotes such as Dictyostelium offers opportunities to investigate functional specificity of MAPKs in G protein-mediated signal transduction pathways. This review considers the regulation and specificity of MAPK function in pathways that control Dictyostelium growth and development.