Ca2+-dependent modulation of GABAA and NMDA receptors by extracellular ATP: implication for function of tripartite synapse.
Ca2+-dependent modulation of GABAA and NMDA receptors by extracellular ATP: implication for function of tripartite synapse.
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细胞外 ATP 对 GABAA 和 NMDA 受体的 Ca2 依赖性调节：对三方突触功能的影响。
DOI：
10.1042/bst0371407
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发表时间：
2009
影响因子：
3.9
通讯作者：
Lalo U
中科院分区：
文献类型：
--
作者：
Lalo U
神经元和神经胶质细胞之间的沟通对大脑功能的重要性被现代的“三重突触”概念所认识。星形胶质细胞包裹突触，并通过释放胶质递质如ATP、谷氨酸和D-丝氨酸来调节其活性。三联突触中的调节途径之一是由P2X嘌呤受体介导的。从突触末梢和星形胶质细胞释放ATP通过P2X嘌呤受体激活Ca 2+内流，P2X嘌呤受体与NMDA（N-甲基-D-天冬氨酸）和GABA（γ-氨基丁酸）受体共定位，并且可以通过涉及磷酸酶II和PKA（蛋白激酶A）的细胞内级联调节它们的活性。
The importance of communication between neuronal and glial cells for brain function is recognized by a modern concept of ‘tripartite synapse’. Astrocytes enwrap synapses and can modulate their activity by releasing gliotransmitters such as ATP, glutamate andD-serine. One of the regulatory pathways in the tripartite synapse is mediated by P2X purinoreceptors. Release of ATP from synaptic terminals and astrocytes activates Ca2+influx via P2X purinoreceptors which co-localize with NMDA (N-methyl-D-aspartate) and GABA (γ-aminobutyric acid) receptors and can modulate their activity via intracellular cascades which involve phosphatase II and PKA (protein kinase A).
钙调神经磷酸酶（磷酸酶 2B）和钙调蛋白对大鼠海马 NMDA 受体的抑制相互作用
影响因子：
4.7
作者：
B. Rycroft;A. Gibb
通讯作者：
A. Gibb