Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease
Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease
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DOI：
10.1183/13993003.02320-2019
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发表时间：
2020-08-01
影响因子：
24.3
通讯作者：
Bartel, Sabine
中科院分区：
文献类型：
--
作者：
Gosens, Reinoud;Hiemstra, Pieter S.;Bartel, Sabine
慢性呼吸道疾病在全球范围内高度流行，并且在可预见的未来将继续上升。尽管近几十年来进行了大量的努力，但新的有效治疗方法的开发一直很缓慢。然而，越来越多的新证据表明，我们体内的微生物群落，即人类微生物组，与慢性呼吸道疾病的发展和进展密切相关。了解宿主和微生物群之间这种相互作用的详细机制对于开发微生物组或宿主靶向治疗和预防策略至关重要。在这里，我们回顾和讨论的最新知识的宿主和微生物之间的持续相互作用的健康和呼吸道疾病。此外，我们强调了基于微生物组的疗法的有希望的发展，并讨论了采用更全面的方法来恢复肺生态位和微生物群落的必要性。
Chronic respiratory diseases are highly prevalent worldwide and will continue to rise in the foreseeable future. Despite intensive efforts over recent decades, the development of novel and effective therapeutic approaches has been slow. However, there is new and increasing evidence that communities of micro-organisms in our body, the human microbiome, are crucially involved in the development and progression of chronic respiratory diseases. Understanding the detailed mechanisms underlying this cross-talk between host and microbiota is critical for development of microbiome- or host-targeted therapeutics and prevention strategies. Here we review and discuss the most recent knowledge on the continuous reciprocal interaction between the host and microbes in health and respiratory disease. Furthermore, we highlight promising developments in microbiome-based therapies and discuss the need to employ more holistic approaches of restoring both the pulmonary niche and the microbial community.