EFFECT OF AGING AND CALORIC RESTRICTION ON INTESTINAL PERMEABILITY
EFFECT OF AGING AND CALORIC RESTRICTION ON INTESTINAL PERMEABILITY
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DOI：
10.1016/0531-5565(92)90059-9
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发表时间：
1992-01-01
影响因子：
3.9
通讯作者：
KRUGLIAK, P
中科院分区：
文献类型：
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作者：
MA, TY;HOLLANDER, D;KRUGLIAK, P
肠通透性在几种疾病中增加，如克罗恩病或类风湿性关节炎。由于衰老导致许多生物学功能的改变，通过用不同大小的渗透性探针-甘露醇、聚乙二醇（PEG）400和菊粉灌胃测定衰老大鼠的肠道渗透性来研究衰老对肠道渗透性的影响。在喂食对照饮食的大鼠中，肠对中等大小的探针PEG 400的渗透性显著增加（3个月和28个月时分别为14.8 ± 0.4和21.0 ± 1.1%，p <0.01）和甘露醇（3个月和28个月时分别为3.41 +/- 0.4和5.3 +/- 0.5%，p <0.01）。大分子菊糖的肠道渗透性未随老化而变化（3个月和28个月时分别为0.42 +/- 0.03和0.38 +/- 0.02%）。大鼠体重与肠道通透性无相关性。由于饮食热量限制已被发现可以延长寿命，延缓几种生物功能的恶化，并影响肠道吸收功能，我们研究了终身热量限制对肠道通透性变化的影响。终身限制热量饮食并不影响与年龄相关的肠道通透性变化。我们的结论是，肠通透性的中型探头随着年龄的增长，终身热量限制并不能阻止这种变化。我们推测，年龄相关的肠屏障功能的恶化可能会增加全身吸收的内腔抗原，并可能有助于抗原相关的年龄相关疾病的发生。
Intestinal permeability is increased in several disorders such as Crohn's disease or rheumatoid arthritis. Since aging leads to alteration of many biological functions, the effect of aging on intestinal permeability was studied by measuring the intestinal permeability in aging rats gavaged with different size permeability probes-mannitol, polyethylene glycol (PEG) 400, and inulin. In rats fed with control diet, there was a significant increase in intestinal permeability to medium size probes PEG 400 (14.8 +/- 0.4 and 2 1.0 +/- 1.1% at 3 and 28 months respectively, p < .01) and mannitol (3.41 +/- 0.4 and 5.3 +/- 0.5% at 3 and 28 months, respectively, p < .01). Intestinal permeability of the large macromolecule inulin did not change (0.42 +/- 0.03 and 0.38 +/- 0.02% at 3 and 28 months, respectively) with aging. There was no correlation between weight of the rats and their intestinal permeability. Because dietary caloric restriction has been found to prolong the life span, retard deterioration of several biological functions, and affect intestinal absorptive functions, we examined the effect of lifelong calorie restriction on intestinal permeability changes. Lifelong calorie-restricted diet did not affect age-related change in intestinal permeability. We conclude that intestinal permeability of medium size probes increases with aging and that lifelong caloric restriction does not prevent this change. We speculate that age-associated deterioration in intestinal barrier functions could permit increased systemic absorption of lumenal antigens and could perhaps contribute to the genesis of antigen-related age-associated diseases.