Q‐Switched Alexandrite Laser Treatment of Oral Labial Lentigines in Chinese Subjects with Peutz‐Jeghers Syndrome
Q‐Switched Alexandrite Laser Treatment of Oral Labial Lentigines in Chinese Subjects with Peutz‐Jeghers Syndrome
复制标题
Q 开关紫翠玉激光治疗中国黑斑息肉综合征受试者口腔唇雀斑
作者：
Z. Xi;Q. Hui;L. Zhong
背景Peutz-Jeghers综合征（PJS）的特征是胃肠道错构瘤性息肉和可见的粘膜皮肤雀斑样痣，分布在口腔和肛门粘膜、手、脸和指甲中。虽然有许多关于成功治疗PJS肠息肉的报道，但关于治疗雀斑样痣的信息很少。Q开关激光是治疗良性黑素细胞病变的首选方法。目的评价Q开关翠绿宝石激光（QSAL）治疗PJS口唇雀斑样痣的疗效。方法和材料：2005年至2008年，对14例诊断为PJS的患者进行了激光治疗。所有患者均使用QSAL进行单次治疗，使用3 mm手柄，能量密度为4.0 - 9.0 J/cm 2。对QSAL的效果进行了回顾性分析。结果14例患者经一次激光治疗后，所有治疗过的雀斑样痣均成功消除。有明显的急性副作用。中位随访2年后，治疗部位无复发或瘢痕。结论：QSAL为去除PJS相关的唇雀斑提供了有效的治疗方法。提交人没有表示对商业支持者有很大的兴趣。
BACKGROUND Peutz‐Jeghers syndrome (PJS) is characterized by gastrointestinal hamartomatous polyps and visible mucocutaneous lentigines distributed in the oral and anal mucosa, hands, face, and nails. Although there are many reports regarding successful treatment of intestinal polyps of PJS, there is little information regarding treatment of lentigines. Q‐switched lasers are the preferred method of treatment for benign melanocytic lesions. OBJECTIVE To evaluate the efficacy of the Q‐switched alexandrite laser (QSAL) in treating oral labial lentigines of PJS. METHODS AND MATERIALS Fourteen cases of laser treatment of oral labial lentigines in patients diagnosed with PJS were studied between 2005 and 2008. All were treated using a single treatment with a QSAL with a 3‐mm handpiece and a fluence of 4.0 to 9.0 J/cm2. Retrospective analysis of the effect of QSAL was conducted. RESULTS All 14 cases exhibited successful elimination of treated lentigines after one laser treatment. There were significant acute side effects. After a median 2‐year follow‐up, there were no recurrences or scars in treated sites. CONCLUSIONS The QSAL provides effective treatment for removal of labial lentigines associated with PJS. The authors have indicated no significant interest with commercial supporters.