Low-Dose Physical Activity Attenuates Cardiovascular Disease Mortality in Men and Women With Clustered Metabolic Risk Factors
Low-Dose Physical Activity Attenuates Cardiovascular Disease Mortality in Men and Women With Clustered Metabolic Risk Factors
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DOI：
10.1161/circoutcomes.112.965434
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发表时间：
2012-07-01
影响因子：
6.9
通讯作者：
Stamatakis, Emmanuel
中科院分区：
文献类型：
--
作者：
Hamer, Mark;Stamatakis, Emmanuel
研究背景--体育活动可以改善代谢紊乱对健康的危害，但证据并不确定，而且对最低保护阈值的估计仍不清楚（年龄54.1 +/- 12.7岁[平均值+/- SD]，45.2%的男性）基线时没有已知的心血管疾病史，他们来自英格兰健康调查和苏格兰健康调查。根据血压、高密度脂蛋白胆固醇、糖尿病、腰围和低度炎症（C反应蛋白>= 3 mg/L），参与者被分为代谢健康（零或一个代谢异常）或不健康（>= 2个代谢异常）。在基线时评估自我报告的体力活动。考克斯比例风险模型被用来检查聚集的代谢风险和体力活动与死亡率的关系，控制年龄，性别，吸烟，社会经济群体，心血管疾病药物治疗和自我评价的健康。在7.0 +/- 3.0年的随访中，分别有2264例全因死亡和717例心血管疾病死亡。研究发现，每周至少1至2次的身体活动阈值可以防止死亡。与活跃/代谢健康的人相比，有聚集性代谢异常的活跃者患心血管疾病的风险并不高（风险比，0.82; 95% CI，0.54-1.26）或全因死亡率（风险比，1.11; 95%CI，0.89-1.39），尽管他们不活动的对应者患心血管疾病的风险升高（危害比，1.41; 95%CI，1.05-1.91）和全因死亡率（危害比，1.50; 95%CI，1.27-1.78）。结论：在那些身体活动的人中，与代谢健康不良相关的心血管疾病的风险显著降低。至少，每周一次中度到剧烈的体力活动对聚集性代谢异常的男性和女性有保护作用。(Circ血管定性结局。2012; 5：494-499）。
Background-Physical activity may ameliorate the health hazards of metabolic disorders but evidence is inconclusive, and estimates of the minimal threshold for protection remain unknown.Methods and Results-The sample comprised 23 747 men and women (aged 54.1 +/- 12.7 years [ mean +/- SD], 45.2% men) without a known history of cardiovascular disease at baseline who were drawn from the Health Survey for England and the Scottish Health Survey. Based on blood pressure, high-density lipoprotein cholesterol, diabetes, waist circumference, and low-grade inflammation (C-reactive protein >= 3 mg/L), participants were classified as metabolically healthy (zero or one metabolic abnormality) or unhealthy (>= 2 metabolic abnormalities). Self-reported physical activity was assessed at baseline. Cox proportional hazards models were used to examine the association of clustered metabolic risk and physical activity with mortality, controlling for age, sex, smoking, socioeconomic group, cardiovascular disease medication, and self-rated health. Over 7.0 +/- 3.0 years follow-up, there were 2264 all-cause and 717 cardiovascular disease deaths, respectively. A physical activity threshold of at least one to 2 sessions per week was found to provide protection against mortality. Compared with active/metabolically healthy, the active with clustered metabolic abnormalities were not at elevated risk of cardiovascular disease (hazard ratio, 0.82; 95% CI, 0.54-1.26) or all-cause mortality (hazard ratio, 1.11; 95% CI, 0.89-1.39), although their inactive counterparts were at elevated risk of cardiovascular disease (hazard ratio, 1.41; 95% CI, 1.05-1.91) and all-cause mortality (hazard ratio, 1.50; 95% CI, 1.27-1.78).Conclusions-The risk of cardiovascular disease associated with poor metabolic health is substantially lower among those who are physically active. At minimum, a weekly bout of moderate to vigorous physical activity is protective in men and women with clustered metabolic abnormalities. (Circ Cardiovasc Qual Outcomes. 2012; 5:494-499.)