Antisense RNA in imprinting:: spreading silence through Air
Antisense RNA in imprinting:: spreading silence through Air
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DOI：
10.1016/s0168-9525(02)02749-x
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发表时间：
2002-09-01
影响因子：
11.4
通讯作者：
Heard, E
中科院分区：
文献类型：
--
作者：
Rougeulle, C;Heard, E
在一些动物中，包括哺乳动物，许多基因的表达是不同的，这取决于它们是从母亲还是从父亲那里遗传的，通过一个被称为基因组印记的过程。非编码RNA越来越多地被发现与印记基因有关，但它们的作用（如果有的话）仍然是个谜。最近的一项研究提供了第一个证据，至少在一种情况下，非编码RNA在顺式调节印迹基因表达中具有直接作用。
In some animals, including mammals, a number of genes are expressed differently according to whether they have been inherited from the mother or from the father, through a process known as genomic imprinting. Noncoding RNAs have increasingly been found associated with imprinted genes, but their role, if any, has remained enigmatic. A recent study provides the first evidence that, at least in one case, a noncoding RNA has a direct role in regulating imprinted gene expression in cis.