Global Histone H3K27 Methylation Levels are Different in Localized and Metastatic Prostate Cancer
Global Histone H3K27 Methylation Levels are Different in Localized and Metastatic Prostate Cancer
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DOI：
10.3109/07357907.2011.636117
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发表时间：
2012-02-01
影响因子：
2.4
通讯作者：
Rogenhofer, Sebastian
中科院分区：
文献类型：
--
作者：
Ellinger, Joerg;Kahl, Philip;Rogenhofer, Sebastian
整体组蛋白修饰模式已被证明是各种癌症复发的预测因素。我们分析了前列腺癌（PCA）组织中的组蛋白-3-赖氨酸-27（H3 K27）甲基化。H3 K27单甲基化、双甲基化和三甲基化模式在非恶性前列腺组织、局限性PCA、转移性PCA和去势抵抗性PCA中不同。H3 K27单甲基化与局部PCA的PT分期、包膜穿透、精囊浸润和Gleason评分相关，因此可能提示不良预后。
Global histone modification patterns have been shown to be a predictive factor of recurrence in various cancers. We analyzed global histone-3-lysine-27 (H3K27) methylation in prostate cancer (PCA) tissues. H3K27 mono-, di-, and tri-methylation patterns were different in nonmalignant prostate tissue, localized PCA, metastatic PCA, and castration-resistant PCA. H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis.