Commensals upon us
Commensals upon us
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DOI：
10.1016/j.bcp.2005.12.040
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发表时间：
2006-03-30
影响因子：
5.8
通讯作者：
Levy, SB
中科院分区：
文献类型：
--
作者：
Alekshun, MN;Levy, SB
通过针对特定物种的抗生素疗法和疫苗，我们的医院和社区正在开展一场控制和减少细菌传染病的战斗。但是这些干预措施对由我们天然微生物植物群的一部分引起的感染的流行病学有什么影响呢？革兰氏阳性菌和革兰氏阴性菌是植物植物群中新的致病菌。这些包括耐万古霉素肠球菌（VRE）、社区相关耐甲氧西林金黄色葡萄球菌（CA-MRSA）、肺炎链球菌的非疫苗侵入性血清型、非B型流感嗜血杆菌的新菌株和多重耐药大肠杆菌。这些例子说明了临床上的改进以及抗生素的广泛使用和滥用是如何推动进化的，从而使通常非致病性的菌株成为对人类健康构成威胁的传染病。(c)2006年爱思唯尔公司All rights reserved.
A battle to control and curtail bacterial infectious diseases is being waged in our hospitals and communities through antibiotic therapies and vaccines targeting specific species. But what effects do these interventions have on the epidemiology of infections caused by the organisms that are part of our natural microbial flora? Gram-positive and gram-negative bacteria appear as new disease agents from among commensal flora. These include vancomycin resistant enterococci (VRE), community-associated methicillin resistant Staphylococcus aureus (CA-MRSA), non-vaccine invasive serotypes of Streptococcus pneumoriiae, new strains of non-type b Haemophilus influenzae and multi-drug resistant Escherichia coli. These examples illustrate how clinical improvements and widespread use and misuse of antibiotics have pushed evolution, allowing normally non-pathogenic strains to become infectious disease threats to human health. (c) 2006 Elsevier Inc. All rights reserved.