Source analysis of event-related cortical activity during visuo-spatial attention
Source analysis of event-related cortical activity during visuo-spatial attention
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DOI：
10.1093/cercor/13.5.486
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发表时间：
2003-05-01
期刊：
影响因子：
3.7
通讯作者：
Hillyard, SA
中科院分区：
文献类型：
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作者：
Di Russo, F;Martínez, A;Hillyard, SA
事件相关电位（ERPs）的记录结合结构和功能磁共振成像（fMRI）研究的时空模式的皮层活动的基础视觉空间注意。小棋盘刺激以随机顺序快速闪烁到视野的四个象限，而受试者每次只注意一个象限中的刺激。注意刺激引起增强的ERP组件的潜伏期范围80-200毫秒，共定位与功能磁共振成像激活在多个纹外皮层区域。最早的ERP组件（C1在50-90毫秒）是不受注意和本地化的偶极子建模距状皮质。然而，在150-225 ms范围内的较长潜伏期偏转（由相同的距状神经源解释）确实显示出与注意力一致的调制。这种迟来的注意力效应，像C1一样，对于上视野刺激和下视野刺激，极性颠倒，与初级视觉皮层（V1区）中的神经发生器一致。这些结果提供了支持，目前的假设，在人类的空间注意力与延迟反馈到V1区从更高的纹外区，可能有功能，提高在出席地点的刺激的显着性。
Recordings of event-related potentials (ERPs) were combined with structural and functional magnetic resonance imaging (fMRI) to study the spatio-temporal patterns of cortical activity that underlie visual-spatial attention. Small checkerboard stimuli were flashed in random order to the four quadrants of the visual field at a rapid rate while subjects attended to stimuli in one quadrant at a time. Attended stimuli elicited enhanced ERP components in the latency range 80-200 ms that were co-localized with fMRI activations in multiple extrastriate cortical regions. The earliest ERP component (C1 at 50-90 ms) was unaffected by attention and was localized by dipole modeling to calcarine cortex. A longer latency deflection in the 150-225 ms range that was accounted for by this same calcarine source, however, did show consistent modulation with attention. This late attention effect, like the C1, inverted in polarity for upper versus lower field stimuli, consistent with a neural generator in primary visual cortex (area V1). These results provide support to current hypotheses that spatial attention in humans is associated with delayed feedback to area V1 from higher extrastriate areas that may have the function of improving the salience of stimuli at attended locations.