The diagnostic value of the native fluorescence visualization device for early detection of premalignant/malignant lesions of the oral cavity
The diagnostic value of the native fluorescence visualization device for early detection of premalignant/malignant lesions of the oral cavity
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DOI：
10.1016/j.pdpdt.2017.10.019
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发表时间：
2018-03-01
影响因子：
3.3
通讯作者：
Mozafari, Pegah Mosannen
中科院分区：
文献类型：
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作者：
Amirchaghmaghi, Maryam;Mohtasham, Nooshin;Mozafari, Pegah Mosannen
目的：本研究的目的是确定一个本地的荧光可视化设备在口腔恶性/发育不良lesions.Methods的识别诊断价值：本研究涉及45例患者谁有口腔病变，被怀疑是恶性的，潜在的恶性，或良性的。患者参观了马什哈德牙科学校的口腔医学系。结果：口腔鳞癌9例，异型增生12例。当用天然荧光可视化装置检查时，10个异型增生病变和所有恶性病变的样本显示为深色或红色/橙子。在90%的异型增生/恶性病变中，无标记荧光结果为阳性。该设备的灵敏度，特异性，阳性和阴性预测值分别为90%，15%，40%，和71%.Conclusions：本机荧光可视化设备可用于在专业中心作为一个诊断设备，以增加临床检查的灵敏度，但由于其特异性低，无法区分良性病变恶性和发育不良的。
Purpose: The present study aimed to determine the diagnostic value of a native fluorescence visualization device in the identification of oral malignant/dysplastic lesions.Methods: This study involved 45 patients who had oral lesions that were suspected to be malignant, potentially malignant, or benign. The patients visited the Oral Medicine Department of the Mashhad Dental School. The sensitivity, specificity, positive and negative predictive values, and likelihood ratio of this device were determined.Results: The histopathological assessment of samples showed 9 cases of oral squamous cell carcinoma and 12 lesions with dysplasia. Ten samples of dysplastic lesions and all malignant lesions appeared dark or red/orange when examined with the native fluorescence visualization device. In 90% of the dysplastic/malignant lesions, the label -free fluorescence results were positive. The sensitivity, specificity, and positive and negative predictive values of this device were 90%, 15%, 40%, and 71%, respectively.Conclusions: The native fluorescence visualization device can be used in specialized centers as an adjunctive device to increase the sensitivity of a clinical examination, but is not capable of distinguishing benign lesions from malignant and dysplastic ones due to its low specificity.