Diet in the aetiology of ulcerative colitis:: A European prospective cohort study
Diet in the aetiology of ulcerative colitis:: A European prospective cohort study
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DOI：
10.1159/000121412
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发表时间：
2008-01-01
期刊：
影响因子：
3.2
通讯作者：
Bingham, Sheila
中科院分区：
文献类型：
--
作者：
Hart, Andrew R.;Luben, Robert;Bingham, Sheila
背景/目的：溃疡性结肠炎的原因尚不清楚，尽管饮食因素可能与此有关。饮食和溃疡性结肠炎的病例对照研究容易受到回忆偏差的影响。这项研究的目的是在一项队列研究中检查营养素的摄入与溃疡性结肠炎的发展之间的预期关系。方法：研究人群为260,686名年龄在20-80岁的男性和女性，他们参加了一项大型欧洲前瞻性队列研究(EPIC)。参与者是英国、瑞典、丹麦、德国或意大利的居民。提供有关饮食的信息，并对受试者进行溃疡性结肠炎的跟踪调查。每个病例与四个对照组相匹配，饮食变量被分成四个分位数。结果：共发现139例溃疡性结肠炎患者。除了从总多不饱和脂肪酸中摄取的能量百分比增加(四分位数趋势OR=1.19(95%CI=0.99-1.43)p=0.07)外，没有发现饮食相关性。结论：除了总多不饱和脂肪酸摄入量较高可能增加风险外，未发现溃疡性结肠炎与饮食之间的相关性。一种生物学机制存在于多不饱和脂肪酸被代谢成促炎介质。
Background/Aims: The causes of ulcerative colitis are unknown, although it is plausible that dietary factors are involved. Case-control studies of diet and ulcerative colitis are subject to recall biases. The aim of this study was to examine the prospective relationship between the intake of nutrients and the development of ulcerative colitis in a cohort study. Methods: The study population was 260,686 men and women aged 20-80 years, participating in a large European prospective cohort study (EPIC). Participants were residents in the UK, Sweden, Denmark, Germany or Italy. Information on diet was supplied and the subjects were followed up for the development of ulcerative colitis. Each incident case was matched with four controls and dietary variables were divided into quartiles. Results: A total of 139 subjects with incident ulcerative colitis were identified. No dietary associations were detected, apart from a marginally significant positive association with an increasing percentage intake of energy from total polyunsaturated fatty acids (trend across quartiles OR = 1.19 (95% CI = 0.99-1.43) p = 0.07). Conclusions: No associations between ulcerative colitis and diet were detected, apart from a possible increased risk with a higher total polyunsaturated fatty acid intake. A biological mechanism exists in that polyunsaturated fatty acids are metabolised to pro-inflammatory mediators.