Histogenesis of yolk sac carcinoma induced by fetectomy in the rat.
Histogenesis of yolk sac carcinoma induced by fetectomy in the rat.
复制标题
大鼠胎儿切除诱导卵黄囊癌的组织发生。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
M. Aizawa
中科院分区：
文献类型：
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作者：
S. Teshima;S. Sakashita;Y. Kikuchi;M. Aizawa
在妊娠第12天取出胎鼠的孕鼠发生了胚胎发育不良的肿瘤。127只手术大鼠中103只发生肿瘤，病理组织学检查为卵黄囊癌52例，腺癌34例，绒毛膜癌8例，畸胎瘤74例。恶性肿瘤的诱发依赖于用于交配的雄性大鼠和胎儿切除的时间。在胎儿切除术前用低剂量照射杀死原始生殖细胞可降低肿瘤的发生。这些发现表明，恶性肿瘤，包括卵黄囊癌，可能是生殖细胞起源。
Pregnant rats whose fetuses were removed on the 12th day of gestation developed tumors dysontogenetically. Out of 127 operated rats, 103 rats gave rise to tumors, which were histologically yolk sac carcinomas (52 cases), adenocarcinomas (34 cases), choriocarcinomas (8 cases) and teratomas (74 cases). Induction of malignant tumors was dependent on the male rats used for mating and the time of fetectomy. Killing of primordial germ cells by low-dose irradiation before fetectomy decreased the occurrence of tumors. These findings indicate that malignant tumors, including yolk sac carcinoma, might be of germ cell origin.