Age-related similarities and differences in cognitive and neural processing revealed by task-related microstate analysis
Age-related similarities and differences in cognitive and neural processing revealed by task-related microstate analysis
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DOI：
10.1016/j.neurobiolaging.2024.01.007
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发表时间：
2024-01-28
影响因子：
4.2
通讯作者：
Hartley，Alan A.
中科院分区：
文献类型：
--
作者：
Denaro，Chandlyr M.;Reed，Catherine L.;Hartley，Alan A.
我们探讨了四种认知功能与衰老相关的神经处理差异。除了ERP分析，我们还包括任务相关的微观状态分析，该分析确定了头皮神经活动随时间的稳定状态，以探索全头神经激活差异。年轻人和老年人（YA，OA）完成了面部知觉（N170），词对判断（N400），视觉oddball（P3）和侧翼（ERN）任务。不同的任务，与工作相关的影响也不同。尽管与年龄相关的延迟潜伏期，N170 ERP和microstate分析表明没有年龄相关的差异幅度或microstate。然而，年龄相关的条件差异，发现P3和N 00振幅和头皮地形：较小的条件差异，发现在OAs以及更广泛的centroparietal头皮分布。年龄组比较的ERN显示类似的局灶性额中央激活位点，但差异激活模式。我们的研究结果不同的年龄影响的任务是最一致的STAC-r框架，提出年龄相关的影响不同，这取决于可用的资源和各种任务所需的处理和认知负荷。
We explored neural processing differences associated with aging across four cognitive functions. In addition to ERP analysis, we included task-related microstate analyses, which identified stable states of neural activity across the scalp over time, to explore whole-head neural activation differences. Younger and older adults (YA, OA) completed face perception (N170), word-pair judgment (N400), visual oddball (P3), and flanker (ERN) tasks. Age-related effects differed across tasks. Despite age-related delayed latencies, N170 ERP and microstate analyses indicated no age-related differences in amplitudes or microstates. However, age-related condition differences were found for P3 and N00 amplitudes and scalp topographies: smaller condition differences were found for in OAs as well as broader centroparietal scalp distributions. Age group comparisons for the ERN revealed similar focal frontocentral activation loci, but differential activation patterns. Our findings of differential age effects across tasks are most consistent with the STAC-r framework which proposes that age-related effects differ depending on the resources available and the kinds of processing and cognitive load required of various tasks.