Clinical radiation sensitivity with DNA repair disorders: an overview.
Clinical radiation sensitivity with DNA repair disorders: an overview.
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DOI：
10.1016/j.ijrobp.2009.02.057
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发表时间：
2009-08-01
影响因子：
7
通讯作者：
Gatti, Richard A.
中科院分区：
文献类型：
--
作者：
Pollard, Julianne M.;Gatti, Richard A.
关键词：
放射治疗的不良反应是放射肿瘤学中一种令人困惑的现象。这些反应是罕见的，许多与患有DNA修复障碍的人有关，如共济失调-毛细血管扩张症(A-T)和奈梅亨断裂综合征(NBS)。详细描述这种情况的文献寥寥无几。本概述描述了四种典型情况，另外32个案例的综合清单，以及从这一总体经验中收集的一些见解。超过一半的报告与范可尼贫血有关。导致反应的最低剂量为3GyA-T患者。大多数患者在接触病毒后几个月内死亡。显然，本文讨论的患者除了癌症外，还患有复杂的疾病，而实施的放射治疗很可能是他们最好的选择。然而，潜在的DNA修复缺陷使传统的放射治疗剂量变得危险。我们的综述支持了先前的智慧，即要么应该避免放射治疗，要么应该非常谨慎地选择剂量，在这些对辐射敏感的基因型必须被其特有的表型识别的情况下，直到更快速、可靠和有效的DNA修复检测变得可用。
Adverse reactions to radiation therapy represent a confounding phenomenon in Radiation Oncology. These reactions are rare, and many have been associated with individuals with DNA repair disorders such as Ataxia-telangiectasia (A-T) and Nijmegen Breakage Syndrome (NBS). There is a paucity of literature detailing such circumstances. This overview describes four exemplary situations, a comprehensive list of 32 additional cases, and some insights gleaned from this overall experience. Fanconi Anemia was associated with over half of the reports. The lowest dose given to a patient that resulted in a reaction was 3 Gy, given to an A-T patient. Most patients died within months of exposure. It is clear that the patients discussed in this paper had complicated illnesses in addition to cancer, and the radiation therapy that administered was most likely their best option. However, the underlying DNA repair defects make conventional radiation therapy doses dangerous. Our review supports prior wisdom that radiation therapy should either be avoided, or doses should be selected with great care in the case of these radiosensitive genotypes which must be recognized with their characteristic phenotypes, until more rapid, reliable and functional assays of DNA repair become available.
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影响因子：
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