Characterisation of wear particles produced by metal on metal and ceramic on metal hip prostheses under standard and microseparation simulation
Characterisation of wear particles produced by metal on metal and ceramic on metal hip prostheses under standard and microseparation simulation
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DOI：
10.1007/s10856-006-0015-z
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发表时间：
2007-05-01
影响因子：
3.7
通讯作者：
Ingham, Eileen
中科院分区：
文献类型：
--
作者：
Brown, Christopher;Williams, Sophie;Ingham, Eileen
由于磨粒引起的骨溶解和晚期无菌性松动，聚乙烯全髋关节置换术中的金属失效引起了人们对替代轴承的兴趣，例如金属对金属植入物。这一领域的最新进展是开发了一种新型陶瓷-金属种植体。在这种低磨损轴承中产生的磨粒的特征之前还没有确定。这项研究的目的是在标准和不利(微分离)磨损条件下表征金属对金属和陶瓷对金属髋部的磨损颗粒。钴铬磨损颗粒的准确表征是困难的，因为这些颗粒的活性性质使它们不能用酸和碱来分离。开发了一种利用酶消化含润滑剂的血清从金属对金属和陶瓷对金属热等静压模拟中分离金属磨损颗粒的方法。然后用高分辨率扫描电子显微镜表征了在标准和微分离磨损条件下，金属对金属和陶瓷对金属种植体产生的磨损颗粒。从所有模拟中分离出来的磨损颗粒的平均尺寸小于50 nm，具有圆形和不规则的形貌。在任何条件下产生的磨粒大小没有明显差异。
The failure of metal on polyethylene total hip replacements due to wear particle induced osteolysis and late aseptic loosening has focused interest upon alternative bearings, such as metal on metal implants. A recent advance in this field has been the development of a novel ceramic on metal implant. The characteristics of the wear particles generated in this low-wearing bearing have not been previously determined. The aims of this study were to characterise metal wear particles from metal on metal and ceramic on metal hips under standard and adverse (microseparation) wear conditions. Accurate characterisation of cobalt-chrome wear particles is difficult since the reactive nature of the particles prevents them from being isolated using acids and bases. A method was developed to isolate the metal wear particles using enzymes to digest serum containing lubricants from metal on metal and ceramic on metal hip simulations. High resolution scanning electron microscopy was then used to characterise the wear particles generated by both metal on metal and ceramic on metal implants under standard and microseparation wear conditions. The wear particles isolated from all simulations had a mean size of less than 50 nm with a rounded and irregular morphology. No significant difference was found between the size of wear particles generated under any conditions.