RORC and Foxp3 axis in cerebrospinal fluid of patients with Neuro-Behcet's Disease
RORC and Foxp3 axis in cerebrospinal fluid of patients with Neuro-Behcet's Disease
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DOI：
10.1016/j.jneuroim.2011.01.012
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发表时间：
2011-04-01
影响因子：
3.3
通讯作者：
Houman, Habib
中科院分区：
文献类型：
--
作者：
Hamzaoui, Kamel;Haghighi, Afshin Borhani;Houman, Habib
5%-30%的白塞氏病（BD）患者存在神经系统表现。神经白塞氏病（NBD）是由T辅助细胞（Th）引起的，其发展依赖于谱系特异性转录因子的表达。在18名NBD患者和26名对照疾病[16名非炎性神经系统疾病（NIND）和10名归因于白塞氏病（HaBD）的头痛]中评估了TBX 21、GATA 3、RORC、FOXP 3和EBI 3的脑脊液（CSF）mRNA表达。与HaBD和NIND患者相比，NBD患者中TBX 21（Th 1）、RORC（Th 17）和Foxp 3（Treg）的表达增加。EBI 3和Th 2相关GATA 3表达降低（P
Neurological manifestations are present in 5% to 30% of patients with Behcet's disease (BD). Neuro-Behcet's Disease (NBD) is hypothetically caused by T helper (Th) cells, which development is dependent on the expression of lineage-specific transcription factors. Cerebrospinal fluid (CSF) mRNA expression of TBX21, GATA3, RORC, FOXP3 and EBI3 were assessed in 18 NBD patients and 26 controls disease [16 noninflammatory neurological disease (NIND) and 10 headache attributed to Behcet's disease (HaBD)]. Expression of TBX21 (Th1), RORC (Th17) and Foxp3 (Treg) were increased in NBD patients compared to HaBD and NIND patients. EBI3 and Th2-associated GATA3 expressions were found to be decreased (P