NF-kappaB regulation in the immune system.
NF-kappaB regulation in the immune system.
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发表时间：
2002
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通讯作者：
Qiutang Li;I. Verma
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作者：
Qiutang Li;I. Verma
核因子 kappaB (NF-kappaB)/REL 转录因子家族在协调控制免疫反应的多种基因的表达方面发挥着核心作用。由于这些因子参与与从炎症到癌症等疾病相关的关键分子的激活和调节，因此 NF-kappaB 领域的科学活动非常活跃。在这篇综述中，我们重点关注目前对 NF-kappaB 调节及其在免疫系统和炎症性疾病中的作用的理解。我们还讨论了 NF-κB 蛋白作为临床应用中潜在治疗靶点的作用。
The nuclear factor-kappaB (NF-kappaB)/REL family of transcription factors has a central role in coordinating the expression of a wide variety of genes that control immune responses. There has been intense scientific activity in the NF-kappaB field owing to the involvement of these factors in the activation and regulation of key molecules that are associated with diseases ranging from inflammation to cancer. In this review, we focus on our current understanding of NF-kappaB regulation and its role in the immune system and inflammatory diseases. We also discuss the role of NF-kappaB proteins as potential therapeutic targets in clinical applications.